LEUCINE & LYSINE: EFFECT OF TRACER PARTITIONING & DIETARY INDISPENSABLE NITROGEN

亮氨酸

• 批准号: 6305669
• 负责人: VERNON R YOUNG
• 金额: $ 4.04万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-12-01 至 2001-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6305669
• 关键词: clinical research; eating; fasting; human subject; leucine; lysine; nitrogen balance; nutrient requirement; nutrition related tag; radiotracer

Study A: We hypothesize that a different partitioning of leucine and lysine tracers, between fast and fed states, would generate data that would not compromise, significantly, our previous understanding and experimental findings that leucine and lysine requirements as defined by FAO/WHO/UNU (1985) are too low. Hence, we expect further support to the MIT-generated values of dietary IAA minimum requirements. Study B: We hypothesize that a decline in dietary IAAs (from "generous" [studied previously] to "intermediate" levels, at a constant total N intake of 160 mg N/kg/d, would not affect significantly leucine and lysine balances and requirements which would be expected to be similar to those described in our previous studies (MIT leucine requirement at 40 mg/kg/d, and lyine at 30 mg/kg/d).

研究A：我们假设，在禁食和进食状态之间，亮氨酸和赖氨酸示踪剂的不同分配将产生不会显著损害我们先前的理解和实验发现的数据，即FAO/WHO/UNU（1985）定义的亮氨酸和赖氨酸需求量太低。 因此，我们希望进一步支持麻省理工学院产生的饮食IAA最低要求值。研究B：我们假设，在160 mg N/kg/d的恒定总氮摄入量下，饮食中IAAs的下降（从“大量”[先前研究]到“中等”水平）不会显著影响亮氨酸和赖氨酸的平衡和需求，预计这与我们先前研究中描述的相似（MIT亮氨酸需求为40 mg/kg/d，赖氨酸为30 mg/kg/d）。