Dissecting the contribution of IL-17-producing γδ T cells in the pathogenesis of airway diseases

剖析产生 IL-17 的 γT 细胞在气道疾病发病机制中的贡献

• 批准号: nhmrc : GNT1147267
• 负责人: A/Pr Margaret Hibbs
• 金额: $ 72.44万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/dissecting-contribution-il-airway-diseases/1348810
• 关键词: Dissecting; contribution; IL; 17; producing

Airway diseases such as severe steroid-refractory asthma and chronic obstructive pulmonary disease (COPD) are an enormous worldwide burden and have a huge public health impact. Approved drugs for these two diseases provide symptomatic relief but they do not halt the disease process, and curative therapy remains elusive. We have discovered a possible cause of chronic bronchitis, and using advanced techniques we are now probing for ways to turn this discovery into an effective treatment option.

严重类固醇难治性哮喘和慢性阻塞性肺疾病（COPD）等气道疾病是世界范围内的巨大负担，并对公共卫生产生巨大影响。这两种疾病的批准药物提供了症状缓解，但它们不能停止疾病进程，治愈治疗仍然难以捉摸。我们已经发现了慢性支气管炎的一种可能的病因，我们正在利用先进的技术探索将这一发现转化为有效治疗方案的方法。