The role of Src family tyrosine kinases in inflammatory lung disease and cancer

Src 家族酪氨酸激酶在炎症性肺病和癌症中的作用

• 批准号: nhmrc : 487910
• 负责人: A/Pr Margaret Hibbs
• 金额: $ 35.7万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-src-family-disease-cancer/94739
• 关键词: role; Src; family; tyrosine; kinases

We aim to learn why some people develop COPD, a serious lung disease, and adenocarcinoma, a common fatal lung cancer. COPD is mostly caused by cigarette smoke which induces lung inflammation. Lung inflammation, which involves macrophage activation, is a major cancer risk. Macrophages can destroy lung tissue, and they may promote cancer development. We will study the role of Src kinases, which can regulate macrophage activation, which may lead to new treatments for these diseases.

我们的目标是了解为什么有些人会患上慢性阻塞性肺疾病(一种严重的肺部疾病)和腺癌(一种常见的致命肺癌)。慢性阻塞性肺疾病主要是由香烟烟雾引起肺部炎症引起的。涉及巨噬细胞激活的肺部炎症是一种主要的癌症风险。巨噬细胞可以破坏肺组织，它们可能会促进癌症的发展。我们将研究调节巨噬细胞激活的Src激酶的作用，这可能会为这些疾病带来新的治疗方法。