DEFINING SUBPOPULATIONS OF PATHOGENIC MACROPHAGES UNDERLYING LUNG DISEASES

肺部疾病致病性巨噬细胞亚群的定义

• 批准号: nhmrc : 1008298
• 负责人: A/Pr Margaret Hibbs
• 金额: $ 42.71万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/defining-subpopulations-pathogenic-lung-diseases/109299
• 关键词: DEFINING; SUBPOPULATIONS; PATHOGENIC; MACROPHAGES; UNDERLYING

Chronic obstructive pulmonary disease (COPD) is a serious lung disease that afflicts over 1 million people in Australia and adenocarcinoma is a common fatal lung cancer; both are typically caused by cigarette smoking, and macrophage-rich inflammation is a hallmark feature. Macrophages can destroy lung tissue and promote cancer development. Herein we will identify and profile macrophage subpopulations that are associated with lung inflammation and cancer to identify therapeutic targets that may yield novel intervention strategies.

慢性阻塞性肺疾病（COPD）是一种严重的肺部疾病，在澳大利亚有超过100万人受到影响，腺癌是一种常见的致命肺癌;两者通常都是由吸烟引起的，富含巨噬细胞的炎症是一个标志性特征。巨噬细胞能破坏肺组织，促进癌症发展。在此，我们将鉴定和分析与肺部炎症和癌症相关的巨噬细胞亚群，以鉴定可能产生新的干预策略的治疗靶点。