Lyn tyrosine kinase sgnalling cascades

Lyn 酪氨酸激酶信号级联

• 批准号: nhmrc : 513714
• 负责人: A/Pr Margaret Hibbs
• 金额: $ 52.18万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/lyn-tyrosine-kinase-sgnalling-cascades/76619
• 关键词: Lyn; tyrosine; kinase; sgnalling; cascades

Mature red cells develop from hemopoietic stem cells in the adult bone marrow. The production of red blood cells is primarily controlled by the hormone erythropoietin (Epo). Previously we had identified that the protein Lyn must be present inside primitive red blood cells for Epo to stimulate them to become mature functional cells. We will determine the role of several molecules that interact with Lyn including Cbp, Liar and LACM, towards apects of red blood cell development.

成熟的红细胞是由成人骨髓中的造血干细胞发育而来的。红细胞的产生主要由激素促红细胞生成素（Epo）控制。以前，我们已经确定蛋白质林恩必须存在于原始红细胞内，以便促红细胞生成素刺激它们成为成熟的功能细胞。我们将确定与林恩相互作用的几种分子的作用，包括Cbp，Liar和LACM，对红细胞发育的影响。