Defining the cellular and molecular mechanisms underlying autoimmunity using a model of SLE

使用 SLE 模型定义自身免疫的细胞和分子机制

• 批准号: nhmrc : 1008288
• 负责人: A/Pr Margaret Hibbs
• 金额: $ 41.67万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/defining-cellular-molecular-model-sle/109298
• 关键词: Defining; cellular; molecular; mechanisms; underlying

The immune system has to recognize the difference between foreign pathogens, which it should attack, and ourselves, which it should not. Autoimmune diseases, like lupus, occur when our immune systems attack our own tissues due to problems in regulation. We have developed an animal model of lupus that has allowed us to identify major points where immune regulation has failed. Identifying these checkpoints will allow us to design and trial novel therapeutics in lupus.

免疫系统必须认识到它应该攻击的外来病原体和不应该攻击的我们自己之间的区别。自身免疫性疾病，如狼疮，当我们的免疫系统由于调节问题而攻击我们自己的组织时，就会发生。我们开发了一种狼疮动物模型，使我们能够识别免疫调节失败的主要部位。确定这些检查点将使我们能够设计和试验狼疮的新疗法。