CURE--GASTROENTERIC BIOLOGY CENTER

CURE--胃肠生物中心

• 批准号: 2608432
• 负责人: JOHN H WALSH
• 金额: $ 83.9万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-01-15 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2608432
• 关键词: biomedical facility; gastrointestinal disorder; gastrointestinal system

The CURE: VA/UCLA Gastroenteric Biology Center is composed of a cohesive group of physicians and basic scientists with strong independent grant- supported research program in gut biology, with special emphasis upon mucosal physiology and disease. CURE first received NIDDK funding in 1974 as a Center to study peptic ulcer disease and became a Digestive Disease Core Center in 1989. The research emphasis of the center is acquisition of new knowledge about cellular processes and physiological control of the gut and translation of this knowledge into development of therapy for patients with gastrointestinal diseases. CURE initially established its reputation for work in clinical peptic ulcer disease, physiological regulation of acid secretion, and parietal cell mechanisms for secreting acid. More recently, demonstration that Helicobacter pylori is an essential factor in pathogenesis of ordinary peptic ulcer disease has brought new aspects of mucosal cell biology into the forefront as the next frontier of research that CURE will follow in its third decade. The interests and activities of Center members have evolved along with science in this area and now include several facets of gastrointestinal regulatory biology including gastrointestinal regulatory peptides, brain-gut interactions, and membrane transport as well as diseases related to these areas. In addition to the parietal cell, other new mucosal cell models have been developed for studies by Center investigators. Functional bowel disease, inflammatory bowel disease, and other disorders of intestinal mucosal function have joined peptic diseases as clinical applications of basic science. The five scientific cores outlined in this proposal provide ready access to technology and to clinical and biological materials that are essential to the programs of Center members. These cores provide custom antibody production, sophisticated peptide chemistry techniques, access to modern cellular imaging to study membrane proteins and their functions, animal models for studying physiology and pathophysiology, and access to a broad range of techniques and patients for clinical studies. An administrative core provides a wide range of administrative support for members and for Center activities including a dynamic enrichment program. The pilot and feasibility program has provided a successful mechanism for aiding development of new research programs by young investigators, and recipients usually have obtained independent funding. The Center provides an optimal environment for cooperation and collaboration among its investigators, who have had a major impact on mucosal biology and on peptic ulcer disease over the past two decades and promise to have an even larger impact upon expanded research areas with continued support from the Center.

治愈方法：VA/UCLA胃肠道生物学中心由一个凝聚力组成 拥有强大独立授予的医师和基础科学家小组 - 肠道生物学的支持研究计划，特别强调 粘膜生理和疾病。 Cure在1974年首次获得NIDDK资金 作为研究消化性溃疡疾病并成为消化系统疾病的中心 1989年核心中心。该中心的研究重点是收购 有关肠道的细胞过程和生理控制的新知识 并将这种知识转化为患者的治疗发展 胃肠道疾病。 CURE最初确立了其在临床消化性溃疡中的工作声誉 疾病，酸分泌的生理调节和顶壁细胞 分泌酸的机制。最近，演示了 幽门螺杆菌是普通发病机理的重要因素 消化性溃疡病将粘膜细胞生物学的新方面带入 作为治疗将遵循的下一个研究领域的最前沿 第三十年。中心成员的兴趣和活动已经发展 与该领域的科学一起，现在包括 胃肠道调节生物学包括胃肠道调节 肽，大脑相互作用和膜转运以及 与这些地区有关的疾病。除顶壁细胞外，其他 已经开发了新的粘膜细胞模型，用于研究中心 调查人员。功能性肠病，炎症性肠病和 肠粘膜功能的其他疾病也加入了肽疾病 作为基础科学的临床应用。 该提案中概述的五个科学核心可随时可以访问 技术以及临床和生物材料对 中心成员的计划。这些核心提供自定义抗体 生产，复杂的肽化学技术，进入现代 细胞成像研究膜蛋白及其功能，动物 研究生理学和病理生理学的模型，并获得广泛的机会 用于临床研究的技术和患者范围。行政 核心为会员和 中心活动，包括动态丰富计划。飞行员和 可行性计划为协助提供了成功的机制 制定年轻研究者和收件人的新研究计划 通常已经获得了独立的资金。 该中心为合作提供了最佳环境 其调查人员之间的合作，他们对 在过去的二十年中 承诺对扩大的研究领域产生更大的影响 中心的持续支持。