RISK OF OSTEOPOROSIS IN PATIENTS WITH RECENT ONSET SYSTEMIC LUPUS ERYTHMATOSUS

SLE是一种慢性、炎症性、自身免疫性疾病， 加重和缓解。最不可预测的疾病过程是 最有可能发生在疾病的最初几年。 初步证据表明，低骨密度的发生频率增加， 女性狼疮患者的矿物质密度狼疮患者骨密度低的原因 患者不清楚。我们将研究骨质流失是 在发病的头两年加速， 与狼疮疾病及其治疗有关（狼疮疾病 活性、炎症介质水平和/或类固醇负荷）。 这是一项对30名狼疮患者的初步纵向研究， 为期2年。具体目的是：1）测量骨矿物质 在基线和一年随访后，2）估计骨密度（BMD） 一年内骨密度变化率，3）分析 狼疮疾病活动性、炎症介质和 在一年的过程中，每三个月测量一次类固醇负荷， BMD及其变化; 4）探讨狼疮性疾病与骨密度的关系 活动，炎症介质和类固醇负荷测量每三个 在一年的时间里， 形成和骨吸收。

SLE is a chronic, inflammatory, autoimmune disease characterized by exacerbations and remissions. The most unpredictable disease course is most likely to occur during the first few years of the illness. Preliminary evidence has documented an increased frequency of low bone mineral density in women with lupus. The reasons for low BMD in lupus patients are unclear. We will investigate the hypotheses that bone loss is accelerated during the first two years of disease onset and that this loss of bone is related to lupus disease and its treatment (lupus disease activity, levels of inflammatory mediators, and/or steroid burden). This is a pilot, longitudinal study of 30 patients with lupus of less than 2 years duration. The specific aims are: 1) to measure bone mineral density (BMD) at baseline and after one year of follow up, 2) to estimate the rate of change in bone mineral density over one year, 3) to analyze the relationships of lupus disease activity, inflammatory mediators, and steroid burden measured every three months over the course of one year with BMD and change in BMD, and 4) to explore the relationships of lupus disease activity, inflammatory mediators, and steroid burden measured every three months over the course of one year with biochemical markers of bone formation and bone resorption.