RISK OF OSTEOPOROSIS IN PATIENTS WITH RECENT ONSET SYSTEMIC LUPUS ERYTHMATOSUS

近期发病的系统性红斑狼疮患者发生骨质疏松的风险

• 批准号: 6275327
• 负责人: Rosalind Ramsey-Goldman
• 金额: $ 2.26万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6275327
• 关键词: bone density; clinical research; disease /disorder proneness /risk; female; hormone regulation /control mechanism; human subject; inflammation; longitudinal human study; osteoporosis; physiologic bone resorption; steroid hormone; systemic lupus erythematosus; women's health

SLE is a chronic, inflammatory, autoimmune disease characterized by exacerbations and remissions. The most unpredictable disease course is most likely to occur during the first few years of the illness. Preliminary evidence has documented an increased frequency of low bone mineral density in women with lupus. The reasons for low BMD in lupus patients are unclear. We will investigate the hypotheses that bone loss is accelerated during the first two years of disease onset and that this loss of bone is related to lupus disease and its treatment (lupus disease activity, levels of inflammatory mediators, and/or steroid burden). This is a pilot, longitudinal study of 30 patients with lupus of less than 2 years duration. The specific aims are: 1) to measure bone mineral density (BMD) at baseline and after one year of follow up, 2) to estimate the rate of change in bone mineral density over one year, 3) to analyze the relationships of lupus disease activity, inflammatory mediators, and steroid burden measured every three months over the course of one year with BMD and change in BMD, and 4) to explore the relationships of lupus disease activity, inflammatory mediators, and steroid burden measured every three months over the course of one year with biochemical markers of bone formation and bone resorption.

SLE 是一种慢性炎症性自身免疫性疾病，其特征为 恶化和缓解。最难以预测的病程是 最有可能发生在疾病的最初几年。 初步证据表明低骨密度的发生率有所增加 患有狼疮的女性的矿物质密度。狼疮BMD低的原因 患者不清楚。我们将研究以下假设：骨质流失是 在疾病发作的头两年加速，并且这种损失 骨骼的变化与狼疮疾病及其治疗有关（狼疮疾病 活性、炎症介质水平和/或类固醇负荷）。 这是一项针对 30 名患有小于或等于狼疮的患者的试点纵向研究 持续时间2年。具体目标是：1）测量骨矿物质 基线时和一年随访后的密度 (BMD)，2) 进行估计 一年内骨矿物质密度的变化率，3) 进行分析 狼疮疾病活动度与炎症介质的关系 一年内每三个月测量一次类固醇负荷 BMD和BMD的变化，以及4)探讨狼疮疾病的关系 每三个测量一次活动、炎症介质和类固醇负荷 一年中几个月的骨生化标记 骨形成和骨吸收。