West London Healthy Home and Environment Study (WellHome)

西伦敦健康家居和环境研究（WellHome）

• 批准号: NE/W002116/1
• 负责人: Frank Kelly
• 金额: $ 369.56万
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=NE%2FW002116%2F1
• 关键词: West; London; Healthy; Home; Environment

Children growing up in the UK today represent an 'indoor child generation', with most of their activities taking place within enclosed spaces, primarily homes and schools, with chemically diverse and often complex air quality environments. Despite its importance in human exposure terms, links between indoor air quality in its widest sense and public health is a under-researched area, particularly in the UK, with historically greater emphasis placed on outdoor air quality. Given the high incidence rates of childhood respiratory diseases in the UK we need a greater focus on eliminating the known triggers for the exacerbation of respiratory conditions such as asthma including the chemical and biological components of air pollution.Furthermore, although epidemiological research has taught us a great deal about the health effects of air pollution, this has not been matched by toxicological research to define underlying mechanistic pathways. Given progress in both sciences is required to develop understanding of sources and risks we will develop enhanced toxicological approaches to lay the foundation for more effective policy development in years ahead. The ambition of this work is to go beyond a simple comparison of the toxicity of airborne particulate collected at different indoor environments, by integrating toxicological observations across microenvironments into an overall hazard to the individual, hence providing a tool to inform future policy.Moving from the outdoor to indoor environment presents significant challenges to public health research, an ecological problem becomes a personal one; our homes are private spaces where we choose how to behave - smoking, cooking, heating, cleaning, ventilating - and policies encroaching upon that choice can be unpopular and/or inappropriate for specific subgroups. Furthermore, socio-economic circumstances can play a significant role in how much choice we have - housing quality, neighbourhood, insulation, home technology - leading to disparities in exposure as a function of socioeconomic status. As such, the challenges that have faced the research community in addressing the most health relevant components of the outdoor aerosol are significantly magnified by adding a consideration of indoor air, where there are additional sources and unique chemical entities. Often, these additional sources are influenced or dictated by individual and household behaviours within the home. We will reduce the complexity of this challenge by focusing on established indoor and outdoor asthma triggers. Asthma affects one in five households in the UK and often these are children in deprived communities.The programme of research in WellHome creates an innovative long-term research and information resource within an engaged urban community to advance knowledge and awareness of residential air quality, its health impacts and methods to ensure reduced exposure to harmful agents. This community research hub will be designed to directly address the challenges faced by urban communities, with a focus on households with sensitive inhabitants. The programme will be created with, and for, the urban population based in West London, a community with a relatively low socio-economic status and high ambient air pollution concentrations. Through focusing on the indoor:outdoor continuum in a manageable number of homes with a vulnerable child, our intensive monitoring approach, toxicological assessments of chemical and biological PM with activity/time linked health data will provide a novel approach to the issue. Information gained from this community will be generalisable to other inner-city communities throughout England and the devolved administrations of the UK hence extending its usefulness beyond this project and leaving a valuable legacy.

如今，在英国长大的儿童代表着“室内儿童一代”，他们的大部分活动都是在封闭的空间进行的，主要是家庭和学校，那里的化学成分多样，空气质量往往也很复杂。尽管室内空气质量在人体暴露方面很重要，但从最广泛的意义上讲，室内空气质量与公共健康之间的联系是一个研究较少的领域，特别是在英国，历史上更多地强调室外空气质量。鉴于英国儿童呼吸道疾病的高发病率，我们需要更多地关注消除哮喘等呼吸道疾病恶化的已知触发因素，包括空气污染的化学和生物成分。此外，尽管流行病学研究教会了我们许多关于空气污染对健康影响的知识，但毒理学研究尚未与之相匹配，无法确定潜在的机制途径。鉴于需要在这两门科学上取得进展，以加深对来源和风险的了解，我们将开发改进的毒理学方法，为今后更有效的政策制定奠定基础。这项工作的雄心不仅仅是简单地比较在不同室内环境中收集的空气颗粒物的毒性，而是通过将跨微环境的毒理学观察整合到对个人的整体危害中，从而提供一种工具来为未来的政策提供信息。从室外环境转移到室内环境给公共卫生研究带来了巨大的挑战，生态问题变成了个人问题；我们的家园是私人空间，我们在这里选择如何行为--吸烟、做饭、取暖、清洁、通风--而侵犯这种选择的政策可能不受欢迎和/或不适合特定的群体。此外，社会经济环境在我们有多少选择--住房质量、邻里关系、隔热材料、家庭技术--方面可能发挥重要作用，从而导致暴露在社会经济地位方面的差异。因此，通过增加对室内空气的考虑，研究界在解决与健康关系最大的室外气溶胶成分方面面临的挑战被显著放大，因为室内空气中有其他来源和独特的化学实体。通常，这些额外的来源受到家庭中个人和家庭行为的影响或支配。我们将通过关注公认的室内和室外哮喘诱因来降低这一挑战的复杂性。在英国，每五个家庭中就有一个患有哮喘，这些家庭通常是贫困社区的儿童。WellHome的研究计划在积极参与的城市社区内创建了一个创新的长期研究和信息资源，以提高对住宅空气质量及其对健康的影响的知识和意识，以及确保减少接触有害物质的方法。这个社区研究中心的设计将直接应对城市社区面临的挑战，重点是拥有敏感居民的家庭。该计划将与伦敦西部的城市人口一起创建，并为他们服务。伦敦西部是一个社会经济地位相对较低、环境空气污染浓度较高的社区。通过将重点放在有脆弱儿童的可管理数量的家庭的室内：室外连续体上，我们的密集监测方法、化学和生物PM的毒理学评估以及与活动/时间相关的健康数据将为这一问题提供一种新的方法。从这个社区获得的信息将推广到整个英格兰的其他内城社区和英国权力下放的行政当局，从而将其用途扩展到这个项目之外，并留下宝贵的遗产。

项目成果

Application of Infrared and Near-Infrared Microspectroscopy to Microplastic Human Exposure Measurements.

• DOI: 10.1177/00037028231199772
• 发表时间: 2023-10
• 期刊: Applied spectroscopy
• 影响因子: 3.5

Multiple myeloma risk in relation to long-term air pollution exposure - A pooled analysis of four European cohorts

• DOI: 10.1016/j.envres.2023.117230
• 发表时间: 2023-10-12
• 期刊: ENVIRONMENTAL RESEARCH
• 影响因子: 8.3
• 作者: Hvidtfeldt，Ulla Arthur;Chen，Jie;Raaschou-Nielsen，Ole
• 通讯作者: Raaschou-Nielsen，Ole