DRUG EXCRETION IN TRANSPLANT PATIENTS

移植患者的药物排泄

• 批准号: 6275835
• 负责人: Raman Venkataramanan
• 金额: $ 1.91万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6275835
• 关键词: biomarker; blood chemistry; cephalosporins; clinical research; clinical trials; drug metabolism; glomerular filtration; halobenzene; human subject; ion transport; kidney disorder diagnosis; kidney function; kidney pharmacology; kidney transplantation; p aminohippurate; postoperative state; renal tubular transport; urinalysis

Purpose of the study is to assess renal function in renal transplant patients. Kidney function is determined by administering renal markers-- PAH, Iothalamate and Cephalexin to renal transplant pts to study active tubular anionic secretion, filtration, and active tubular secretion. 12 kidney transplant pts will be divided into 2 groups, 6 will receive Iothalamate and PAH over a 3 hr period, the other 6 will receive Cephalexin as a bolus and studied over 8 hrs. Drugs will be assayed in plasma and urine collected, and results compared w/6 normals receiving Ioth/PAH.

本研究的目的是评估肾移植患者的肾功能。 病人。肾功能是通过给予肾脏标记物来确定的-- PAH、异硫氰酸酯和头孢氨苄对肾移植患者的积极研究 肾小管阴离子分泌、滤过和活动性肾小管分泌。12 肾移植患者将分成2组，6名将接受 异硫氰酸酯和PAH在3小时内，其他6人将收到 头孢氨苄作为一种丸剂，研究超过8小时。药品将被检测在 采集血浆和尿液，并将结果与6名正常人进行比较 物联网/多环芳烃。