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DRUG EXCRETION IN TRANSPLANT PATIENTS

DRUG EXCRETION IN TRANSPLANT PATIENTS
移植患者的药物排泄
批准号：
6275835
负责人：
Raman Venkataramanan
金额：
$1.91万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-12-01 至 1998-11-30
来源：
https://reporter.nih.gov/project-details/6275835
关键词：
biomarker blood chemistry cephalosporins clinical research clinical trials drug metabolism glomerular filtration halobenzene human subject ion transport kidney disorder diagnosis kidney function kidney pharmacology kidney transplantation p aminohippurate postoperative state renal tubular transport urinalysis

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中文摘要
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英文摘要
Purpose of the study is to assess renal function in renal transplant patients. Kidney function is determined by administering renal markers-- PAH, Iothalamate and Cephalexin to renal transplant pts to study active tubular anionic secretion, filtration, and active tubular secretion. 12 kidney transplant pts will be divided into 2 groups, 6 will receive Iothalamate and PAH over a 3 hr period, the other 6 will receive Cephalexin as a bolus and studied over 8 hrs. Drugs will be assayed in plasma and urine collected, and results compared w/6 normals receiving Ioth/PAH.
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DRUG EXCRETION IN TRANSPLANT PATIENTS
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