DRUG EXCRETION IN TRANSPLANT PATIENTS

本研究的目的是了解肾移植患者的肾功能。本研究通过给肾移植患者施用肾标志物——多环芳烃、碘甲酸酯和头孢氨苄来测定肾功能，研究肾小管阴离子的活性分泌、滤过和肾小管的活性分泌。12名肾移植患者将被分为两组，6名患者将在3小时的时间内接受碘thalamate和PAH，另外6名患者将接受头孢氨苄作为丸剂，研究超过8小时。收集血浆和尿液进行药物检测，并将结果与接受碘/多环芳烃治疗的1 /6正常人进行比较。

The objective of this study is to access renal function in renal transplant patients. Here kidney function is determined by administering renal markers--PAH, Iothalamate and Cephalexin to renal transplant patients to study active tubular anionic secretion, filtration, and active tubular secretion. 12 kidney transplant patients will be divided into 2 groups, 6 will receive Iothalamate and PAH over a 3 hour period, the other 6 will receive Cephalexin as a bolus and studied over 8 hrs. Drugs will be assayed in plasma and urine collected, and results compared with/6 normals receiving Ioth/PAH.