DRUG EXCRETION IN TRANSPLANT PATIENTS

移植患者的药物排泄

• 批准号: 6219259
• 负责人: Raman Venkataramanan
• 金额: $ 0.3万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6219259
• 关键词: biomarker; blood chemistry; cephalosporins; clinical research; clinical trials; drug metabolism; glomerular filtration; halobenzene; human subject; ion transport; kidney disorder diagnosis; kidney function; kidney pharmacology; kidney transplantation; p aminohippurate; postoperative state; renal tubular transport; urinalysis

The objective of this study is to access renal function in renal transplant patients. Here kidney function is determined by administering renal markers--PAH, Iothalamate and Cephalexin to renal transplant patients to study active tubular anionic secretion, filtration, and active tubular secretion. 12 kidney transplant patients will be divided into 2 groups, 6 will receive Iothalamate and PAH over a 3 hour period, the other 6 will receive Cephalexin as a bolus and studied over 8 hrs. Drugs will be assayed in plasma and urine collected, and results compared with/6 normals receiving Ioth/PAH.

本研究的目的是了解肾移植患者的肾功能。在这里，肾功能是通过给肾移植患者应用肾标记物--PAH、异硫氰酸酯和头孢氨苄来研究活跃的肾小管阴离子分泌、滤过和活跃的肾小管分泌来确定的。12例肾移植患者将被分成2组，其中6例在3小时内接受异硫氰酸酯和PAH治疗，另外6例在8小时内接受头孢氨苄治疗。将采集的血浆和尿液中的药物进行检测，并与6例接受IoTH/PAH治疗的正常人进行比较。