DRUG EXCRETION IN TRANSPLANT PATIENTS

本研究的目的是了解肾移植患者的肾功能。在这里，肾功能是通过给肾移植患者应用肾标记物--PAH、异硫氰酸酯和头孢氨苄来研究活跃的肾小管阴离子分泌、滤过和活跃的肾小管分泌来确定的。12名肾移植患者将被分成两组，6名将在3小时内接受异烟肼(IOH)和PAH治疗，另外6名将接受头孢氨苄片剂治疗，并在8小时内进行研究。将采集的血浆和尿液中的药物进行检测，并与6名接受IoTH/PAH治疗的正常人进行比较。

The objective of this study is to access renal function in renal transplant patients. Here kidney function is determined by administering renal markers--PAH, Iothalamate and Cephalexin to renal transplant patients to study active tubular anionic secretion, filtration, and active tubular secretion. Twelve kidney transplant patients will be divided into two groups, six will receive Iothalamate (IOH) and PAH over a three hour period, the other six will receive Cephalexin as a bolus and studied over eight hours. Drugs will be assayed in plasma and urine collected, and results compared with six normals receiving Ioth/PAH.