DRUG EXCRETION IN TRANSPLANT PATIENTS

本研究的目的是了解肾移植患者的肾功能。本研究通过给肾移植患者施用肾标志物——多环芳烃、碘甲酸酯和头孢氨苄来测定肾功能，研究肾小管阴离子的活性分泌、滤过和肾小管的活性分泌。12名肾移植患者将被分为两组，6名患者将在3小时内接受碘甲酸盐（IOH）和多环芳烃（PAH）治疗，另外6名患者将接受头孢氨苄（Cephalexin）作为丸剂，研究时间超过8小时。将在收集的血浆和尿液中检测药物，并将结果与6名接受碘/多环芳烃治疗的正常人进行比较。

The objective of this study is to access renal function in renal transplant patients. Here kidney function is determined by administering renal markers--PAH, Iothalamate and Cephalexin to renal transplant patients to study active tubular anionic secretion, filtration, and active tubular secretion. Twelve kidney transplant patients will be divided into two groups, six will receive Iothalamate (IOH) and PAH over a three hour period, the other six will receive Cephalexin as a bolus and studied over eight hours. Drugs will be assayed in plasma and urine collected, and results compared with six normals receiving Ioth/PAH.