IONTOPHORESIS AND MICRODIALYSIS TO OPTIMIZE DRUG DELIVERY

离子电渗疗法和微透析可优化药物输送

• 批准号: 6281000
• 负责人: GRAZIA STAGNI
• 金额: $ 1.49万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6281000
• 关键词: clinical research; drug delivery systems; human subject; iontophoresis therapy; method development; microdialysis; pharmacokinetics; transdermal drug delivery; volunteer

Iontophoresis is a drug delivery system used to facilitate the introduction of charged ions across the skin barrier by use of current. It provides the advantages of intravenous infusion withoout the problems associated with the use of needles. But there is poor understanding of the iontophoretic process itself. Intradermal microdialysis is a new technique which permits in vivo sampling of dermal extracellular fluid. The present study proposes to combine iontophoresis with microdialysis to measure the kinetics of transdermal delivery in health volunteers.

离子导入是一种药物输送系统，用于促进