IONTOPHORESIS AND MICRODIALYSIS TO OPTIMIZE DRUG DELIVERY

离子导入是一种药物传递系统，利用电流促进带电离子穿过皮肤屏障。它提供了静脉输液的优点，而不存在与使用针头相关的问题。但人们对离子导入过程本身的了解很少。真皮内微透析是一种允许活体采集真皮细胞外液的新技术。本研究建议将离子导入和微透析相结合，以测量健康志愿者的经皮给药动力学。超声检查被用来确定皮内弹壳的精确深度。

Iontophoresis is a drug delivery system used to facilitate the introduction of charged ions across the skin barrier by use of current. It provides the advantages of intravenous infusion withoout the problems associated with the use of needles. But there is poor understanding of the iontophoretic process itself. Intradermal microdialysis is a new technique which permits in vivo sampling of dermal extracellular fluid. The present study proposes to combine iontophoresis with microdialysis to measure the kinetics of transdermal delivery in healthy volunteers. Ultrasonography is utilized to determine the precise depth of intradermal cartridges.