IONTOPHORESIS AND MICRODIALYSIS TO OPTIMIZE DRUG DELIVERY

离子电渗疗法是一种药物递送系统，用于通过使用电流促进带电离子穿过皮肤屏障的引入。 它提供了静脉输液的优点，而没有与使用针头相关的问题。 但是，人们对离子电渗疗法本身的理解很差。 皮内微透析技术是一种新的皮肤细胞外液取样技术。 本研究拟将联合收割机离子导入与微透析技术相结合，测定健康志愿者的经皮给药动力学。 超声检查用于确定皮内药筒的精确深度。

Iontophoresis is a drug delivery system used to facilitate the introduction of charged ions across the skin barrier by use of current. It provides the advantages of intravenous infusion withoout the problems associated with the use of needles. But there is poor understanding of the iontophoretic process itself. Intradermal microdialysis is a new technique which permits in vivo sampling of dermal extracellular fluid. The present study proposes to combine iontophoresis with microdialysis to measure the kinetics of transdermal delivery in healthy volunteers. Ultrasonography is utilized to determine the precise depth of intradermal cartridges.