IONTOPHORESIS AND MICRODIALYSIS TO OPTIMIZE DRUG DELIVERY

离子导入是一种药物输送系统，用于通过使用电流促进带电离子通过皮肤屏障的引入。它提供了静脉输注的优点，而没有与使用针头相关的问题。但是人们对离子渗透过程本身的了解很少。皮内微透析是一种允许在体内取样真皮细胞外液的新技术。本研究提出结合离子透渗和微透析来测量健康志愿者的透皮给药动力学。超声是用来确定皮内盒的精确深度。

Iontophoresis is a drug delivery system used to facilitate the introduction of charged ions across the skin barrier by use of current. It provides the advantages of intravenous infusion withoout the problems associated with the use of needles. But there is poor understanding of the iontophoretic process itself. Intradermal microdialysis is a new technique which permits in vivo sampling of dermal extracellular fluid. The present study proposes to combine iontophoresis with microdialysis to measure the kinetics of transdermal delivery in healthy volunteers. Ultrasonography is utilized to determine the precise depth of intradermal cartridges.