EFFECTS OF RHIGF-1 AND ESTROGEN ON BONE DENSITY IN ANOREXIA NERVOSA

RHIGF-1 和雌激素对神经性厌食症骨密度的影响

• 批准号: 6280042
• 负责人: STEVEN K. GRINSPOON
• 金额: $ 2.74万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6280042
• 关键词: anorexia nervosa; bone density; bone metabolism; clinical research; combination chemotherapy; estrogens; female; hormone therapy; human subject; human therapy evaluation; insulinlike growth factor; pathologic bone resorption; skeletal disorder chemotherapy; women's health

The purpose of this study is to investigate the effects of nutritional and hormonal factors on bone turnover and bone density in women with anorexia nervosa. One aim of the study will be to determine the time course and quantitative effects of short-term, low dose, rhIGF-I administration on bone turnover in estrogen-treated vs. nonestrogen- treated women with anorexia nervosa. The second aim is to investigate the long term effects of combined estrogen and rhIGF-I on bone density in anorexia nervosa; for this part of the study, anorectic subjects with established bone loss will be randomized to recieve one or both treatments for a period of nine months.

本研究的目的是探讨营养素 和激素因素对女性骨转换和骨密度的影响 神经性厌食症这项研究的一个目的是确定 短期低剂量rhIGF-I的病程和定量效应 给药对雌激素治疗与非雌激素治疗患者骨转换的影响- 治疗神经性厌食症的女性第二个目的是调查 雌激素联合rhIGF-I对骨密度的远期影响 在神经性厌食症中;对于研究的这一部分，厌食症受试者 将随机接受一种或两种治疗， 为期九个月的治疗。