MODELING OF LASER TISSUE INTERACTIONS

这个项目的目的是研究 准分子激光诱导的时间分辨荧光过程 为了制定可靠组织的量化标准 人物刻画。我们的方法包括时间分辨激光诱导 用于识别的荧光测量 不同荧光团的光谱-时间模式特征， 可以作为唯一和明确的“签名” 各种荧光团(胶原蛋白、弹性蛋白、NAD和 NADH)。在这个拨款年度，我们开发了一部小说 激光诱导荧光衰减的方法学/技术 多根光纤作为可靠的在线测量手段 缺血和缺氧。初步结果表明， 这种测量的可行性，创造了有用的前景 在许多外科和诊断程序中的应用。

The aim of this project it to investigate the fundamental time-resolved fluorescence processes induced by excimer lasers in order to develop quantitative criteria for reliable tissue characterization. Our approach involves time-resolved laser-induced fluorescence measurements for the purpose of identification of spectro-temporal patterns characteristic of different fluorophores, which can be used as "signatures" for unique and unambiguous characterization of various fluorophores (collagen, elastin, NAD and NADH). During this grant year, we developed a novel methodology/technology of laser-induced fluorescence attenuation using multiple optic fibers as a means of reliable on-line measurements of ischemia and hypoxia. The initial results have demonstrated the feasibility of such measurements, creating the prospect of useful applications in many surgical and diagnostic procedures.