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MODELING OF LASER TISSUE INTERACTIONS

MODELING OF LASER TISSUE INTERACTIONS
激光组织相互作用的建模
批准号：
6120737
负责人：
WARREN S GRUNDFEST
金额：
$0.1万
依托单位：
UNIVERSITY OF SOUTHERN CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-09-30 至 1999-08-31
来源：
https://reporter.nih.gov/project-details/6120737
关键词：
bioengineering /biomedical engineering biomedical resource cardiovascular system health care surgery technology /technique

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英文摘要
The aim of this project it to investigate the fundamental time-resolved fluorescence processes induced by excimer lasers in order to develop quantitative criteria for reliable tissue characterization. Our approach involves time-resolved laser-induced fluorescence measurements for the purpose of identification of spectro-temporal patterns characteristic of different fluorophores, which can be used as "signatures" for unique and unambiguous characterization of various fluorophores (collagen, elastin, NAD and NADH). During this grant year, we developed a novel methodology/technology of laser-induced fluorescence attenuation using multiple optic fibers as a means of reliable on-line measurements of ischemia and hypoxia. The initial results have demonstrated the feasibility of such measurements, creating the prospect of useful applications in many surgical and diagnostic procedures.
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