NIEHS STATISTICAL CONSULTING SERVICE

NIEHS 统计咨询服务

• 批准号: 6289961
• 负责人: JOSEPH K HASEMAN
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6289961
• 关键词: health science research analysis /evaluation; neoplasm /cancer epidemiology; statistics /biometry; training

The goal of this project is to provide statistical and computational expertise in the design, analysis, and interpretation of experimental results for a variety of Institute research activities, including both laboratory and human studies. Approximately 80 scientists made use of the Statistical Consulting Service in FY99. Many of these activities involved NTPs long term rodent carcinogenicity studies. During FY99 we provided significant input into the preparation of approximately 12 NTP Technical Reports that summarized the results of these studies. We also coauthored papers in the scientific literature dealing with the carcinogenic effects of magnetic fields, ethylbenzene, pentachlorophenol, and molybdenum trioxide. Examples of other collaborations include an assessment of the proliferative target organ effects and control tumor profiles observed in a set of NTP studies in Tg.AC transgenic and p53-heterozygous mice, two genetically altered mouse strains which are of emerging importance in toxicologic pathology. - Statistical consulting; collaborative research; experimental design; data analysis; National Toxicology Program

该项目的目标是为研究所的各种研究活动提供设计、分析和解释实验结果的统计和计算专业知识，包括实验室和人体研究。在1999财政年度，大约有80名科学家使用了统计咨询服务。这些活动中有许多涉及NTPs长期的啮齿动物致癌性研究。在1999财年期间，我们为编写总结这些研究结果的大约12份NTP技术报告提供了大量投入。我们还在科学文献中合著了关于磁场、乙苯、五氯苯酚和三氧化钼致癌效应的论文。其他合作的例子包括对Tg.AC转基因和p53杂合子小鼠的一系列NTP研究中观察到的增殖靶器官效应和控制肿瘤概况的评估，这两个基因改变的小鼠品系在毒理学病理学中正在显现出重要意义。-统计咨询；合作研究；实验设计；数据分析；国家毒理学计划