NIEHS Statistical Consulting Service

NIEHS统计咨询服务

• 批准号: 6504699
• 负责人: JOSEPH K HASEMAN
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6504699
• 关键词: Rodentias; carcinogens; chemical carcinogen; computer data analysis; neoplasm /cancer epidemiology; statistical service /center; statistics /biometry; toxicology information system

The goal of this project is to provide statistical and computational expertise in the design, analysis, and interpretation of experimental and observational studies for a variety of Institute research activities, including both laboratory and human studies. Approximately 80 scientists made use of the Statistical Consulting Service in FY2001. Many of these activities involved NTP's long term rodent carcinogenicity studies. During FY2001 we provided significant input into the preparation of approximately 12 NTP Technical Reports that summarized the results of these studies. We also coauthored a paper in the scientific literature dealing with the carcinogenic effects of magnetic fields. Examples of other collaborations include (i) evaluating the effects of antiretroviral therapy on genetic and morphological endpoints in lymphocytes and sperm of people with HIV infection; (ii) investigating the occurrence of proliferative lesions and reproductive tract tumors in male descendants of mice exposed developmentally to diethylstilbestrol; (iii) evaluating the effects of arsenic, cadmium, chromium, and lead on gene expression regulated by a battery of 13 different promoters in recombinant HepG2 cells; and (iv) designing and implementing a longitudinal study to evaluate the growth and development of uterine fibroids in 300 women of child bearing age.

该项目的目标是为研究所的各种研究活动（包括实验室和人体研究）提供实验和观察研究的设计、分析和解释方面的统计和计算专业知识。 2001 财年，大约有 80 名科学家利用了统计咨询服务。其中许多活动涉及 NTP 的长期啮齿动物致癌性研究。 2001 财年期间，我们为大约 12 份 NTP 技术报告的准备提供了重要的投入，这些报告总结了这些研究的结果。我们还在科学文献中共同撰写了一篇有关磁场致癌作用的论文。其他合作的例子包括（i）评估抗逆转录病毒治疗对艾滋病毒感染者淋巴细胞和精子的遗传和形态学终点的影响； (ii) 研究发育中暴露于己烯雌酚的小鼠雄性后代中增殖性病变和生殖道肿瘤的发生情况； (iii) 评估砷、镉、铬和铅对重组 HepG2 细胞中由 13 种不同启动子组成的基因表达调控的影响； (iv) 设计并实施一项纵向研究，以评估 300 名育龄妇女子宫肌瘤的生长和发育情况。