NIEHS Statistical Consulting Service

统计咨询服务（SCS）于1996年正式成立，旨在为研究所研究活动的实验结果的设计，分析和解释提供统计和计算专业知识。SCS提供的统计专业知识包括有关数据分析的建议，以及更广泛的合作研究工作，这些工作导致在主题期刊上联合发表文章。这些咨询项目涉及各种科学工作，包括实验室和人体研究。来自生物统计分支的一些统计学家在不同程度上参与了SCS。本资源审查报告总结了上述生物统计分支统计学家为实验室研究项目提供的咨询/合作。在2003财政年度，大约有80名科学家使用了SCS。 其中许多活动涉及国家毒理学计划（NTP）的长期啮齿动物致癌性研究。在2003财政年度，我们为编写约10份总结这些研究结果的NTP技术报告提供了重要投入。其中三个项目还在科学文献中联合发表了论文。其他已发表的合作案例包括 (i)在雄性F344大鼠的颗粒化合物吸入研究中，评价肾上腺嗜铬细胞瘤发生率与肺病理学之间的相关性。 (ii)开发小鼠前列腺和精囊的最佳修剪和包埋方法，以确保充分、一致的采样。 (iii)端粒酶活性诱导人子宫平滑肌瘤细胞和子宫肌层细胞系永生化的研究 (iv)在吸入研究中暴露于颗粒物的雄性B6 C3 F1小鼠的全身血管疾病评价。 (v)评价慢性进行性肾病对F344大鼠肾小管肿瘤发生率的影响。 (vi)在子宫内暴露于低剂量双酚A的两种大鼠品系的性发育研究。 (vii)影响子宫营养生物测定中使用的未成熟CD-1小鼠子宫重量的饮食因素的检查。 （viii）开发用于评估TRAMP模型中前列腺增生性病变的分级方案。 (ix)对雌性Sprague-Dawley大鼠长期接受TCDD和PCB 126治疗后的心血管病理学进行了研究。 (x)评价短期暴露于Riddelliine后内皮细胞凋亡、有丝分裂、S期、p53和肝细胞血管内皮生长因子表达。 (xi)检查出生后第91-97天灌胃双酚A对成年Sprague-Dawley大鼠精子生成的影响。 (xii)评价膳食植物雌激素对未成熟CD-1小鼠阴道开放时间的影响。

The Statistical Consulting Service (SCS) was formally established in 1996 to provide statistical and computational expertise in the design, analysis, and interpretation of experimental results from Institute research activities. Statistical expertise provided by the SCS ranges from advice regarding data analysis to more extensive collaborative research efforts that result in joint publications in subject matter journals. These consulting projects involve a variety of scientific endeavors, including both laboratory and human studies. A number of statisticians from the Biostatistics Branch are involved in varying degrees with the SCS. This Resource Review report summarizes the consulting/collaborations provided by theBiostatistics Branch statisticians identified above for projects dealing with laboratory research. Approximately 80 scientists made use of the SCS in FY2003. Many of these activities involved the National Toxicology Program's (NTP's) long term rodent carcinogenicity studies. During FY2003 we provided significant input into the preparation of approximately 10 NTP Technical Reports that summarized the results of these studies. Three of these have also resulted in joint publications in the scientific literature. Examples of other published collaborations include (i) an evaluation of the association between the occurrence of adrenal pheochromocytoma and lung pathology in inhalation studies with particulate compounds in the male F344 rat. (ii) the development of an optimal trimming and embedding method for mouse prostate and seminal vesicles to ensure adequate, consistent sampling. (iii) an investigation of the immortalization of human uterine leiomyoma and myometrial cell lines after induction of telomerase activity. (iv) an evaluation of systemic vascular disease in male B6C3F1 mice exposed to particulate matter in inhalation studies. (v) an evaluation of the effect of chronic progressive nephropathy on the incidence of renal tubule neoplasms in the F344 rat. (vi) an investigation of sexual development in two strains of rats exposed in utero to low doses of Bisphenol A. (vii) an examination of the dietary factors affecting uterine weights of immature CD-1 mice used in uterotrophic bioassays. (viii) the development of a grading scheme for the assessment of proliferative lesions of the prostate in the TRAMP model. (ix) an investigation of cardiovascular pathology in female Sprague-Dawley rats following chronic treatment with TCDD and PCB126. (x) an evaluation of endothelial apoptosis, mitosis, S phase, p53 and hepatocytic vascular endothelial growth factor expression after short-term exposure to riddelliine. (xi) an examination of the effect on sperm production in adult Sprague-Dawley rats exposed by gavage to Bisphenol A between postnatal days 91-97. (xii) an evaluation of the effect of dietary phytoestrogens on the time of vagnal opening in immature CD-1 mice.