NIEHS Statistical Consulting Service

统计咨询处(SCS)于1996年正式成立，在设计、分析和解释研究所研究活动的实验结果方面提供统计和计算方面的专门知识。统计司提供的统计专门知识范围从关于数据分析的建议到更广泛的合作研究努力，从而在专题期刊上联合发表文章。这些咨询项目涉及各种科学努力，包括实验室和人体研究。生物统计处的一些统计员在不同程度上参与了统计司的工作。这份资源审查报告概述了上述生物统计科统计员为实验室研究项目提供的咨询/合作。在2003财年，大约有80名科学家使用了SCS。 其中许多活动涉及国家毒理学计划(NTP)的长期啮齿动物致癌性研究。在2003财政年度期间，我们为编写总结这些研究结果的大约10份国家核技术方案技术报告提供了大量投入。其中三项还导致在科学文献上发表了联合出版物。其他已发表合作的例子包括 (I)在吸入颗粒物研究中，对雄性F344大鼠肾上腺嗜铬细胞瘤的发生与肺部病理之间的关系进行评估。 (Ii)开发一种最佳的小鼠前列腺和精囊的修剪和包埋方法，以确保充分、一致的采样。 (3)人子宫肌瘤和子宫肌层细胞系在端粒酶活性诱导后永生化的研究。 (Iv)评价吸入研究中暴露于颗粒物的雄性B6C3F1小鼠的全身血管疾病。 (V)评估慢性进行性肾病对F344大鼠肾小管肿瘤发生率的影响。 (Vi)对子宫内暴露于低剂量双酚A的两种品系大鼠性发育的调查。 (Vii)用于子宫营养生物测定的影响未成熟CD-1小鼠子宫重量的饮食因素的检查。 (Viii)制定用于评估TRAMP模型中的前列腺增生性病变的分级方案。 (Ix)对长期服用TCDD和PCB126的雌性SD大鼠的心血管病理进行调查。 (X)评价短期暴露于吡德利林后内皮细胞的凋亡、有丝分裂、S时相、P53蛋白和肝细胞血管内皮生长因子的表达。 (Xi)观察出生后第91-97天双酚A对成年SD大鼠精子生成的影响。 (Xii)评价饮食中植物雌激素对CD-1幼鼠开放时间的影响。

The Statistical Consulting Service (SCS) was formally established in 1996 to provide statistical and computational expertise in the design, analysis, and interpretation of experimental results from Institute research activities. Statistical expertise provided by the SCS ranges from advice regarding data analysis to more extensive collaborative research efforts that result in joint publications in subject matter journals. These consulting projects involve a variety of scientific endeavors, including both laboratory and human studies. A number of statisticians from the Biostatistics Branch are involved in varying degrees with the SCS. This Resource Review report summarizes the consulting/collaborations provided by theBiostatistics Branch statisticians identified above for projects dealing with laboratory research. Approximately 80 scientists made use of the SCS in FY2003. Many of these activities involved the National Toxicology Program's (NTP's) long term rodent carcinogenicity studies. During FY2003 we provided significant input into the preparation of approximately 10 NTP Technical Reports that summarized the results of these studies. Three of these have also resulted in joint publications in the scientific literature. Examples of other published collaborations include (i) an evaluation of the association between the occurrence of adrenal pheochromocytoma and lung pathology in inhalation studies with particulate compounds in the male F344 rat. (ii) the development of an optimal trimming and embedding method for mouse prostate and seminal vesicles to ensure adequate, consistent sampling. (iii) an investigation of the immortalization of human uterine leiomyoma and myometrial cell lines after induction of telomerase activity. (iv) an evaluation of systemic vascular disease in male B6C3F1 mice exposed to particulate matter in inhalation studies. (v) an evaluation of the effect of chronic progressive nephropathy on the incidence of renal tubule neoplasms in the F344 rat. (vi) an investigation of sexual development in two strains of rats exposed in utero to low doses of Bisphenol A. (vii) an examination of the dietary factors affecting uterine weights of immature CD-1 mice used in uterotrophic bioassays. (viii) the development of a grading scheme for the assessment of proliferative lesions of the prostate in the TRAMP model. (ix) an investigation of cardiovascular pathology in female Sprague-Dawley rats following chronic treatment with TCDD and PCB126. (x) an evaluation of endothelial apoptosis, mitosis, S phase, p53 and hepatocytic vascular endothelial growth factor expression after short-term exposure to riddelliine. (xi) an examination of the effect on sperm production in adult Sprague-Dawley rats exposed by gavage to Bisphenol A between postnatal days 91-97. (xii) an evaluation of the effect of dietary phytoestrogens on the time of vagnal opening in immature CD-1 mice.