NTP DATABASE SUMMARIZATION AND EVALUATION

NTP数据库总结与评估

• 批准号: 6106656
• 负责人: JOSEPH K HASEMAN
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6106656
• 关键词: cancer information system; chemical carcinogen; chemical carcinogenesis; chemical information system; decision making; health science research analysis /evaluation; human data

In addition to publishing updated tumor rates in control Fischer 344 rats and B6C3F1 mice, we compared the results of a number of chemicals evaluated both in NTP rodent carcinogenicity studies and in genetically altered mice. Preliminary results indicated that genetically altered mice have the potential to serve as more rapid and less expensive test systems to identify carcinogens. Twelve chemicals in the NTP database were identified that produced nasal cavity tumors. We found that most of the nasal carcinogens (1) produced tumor increases in both sexes, (2) produced tumors at other sites as well, (3) had significantly reduced survival at doses that were carcinogenic, and (4) were genotoxic. Finally, we found a striking inverse correlation between the incidences of pituitary gland tumors and testis adenoma in control male F344 rats. In dermal and inhalation studies, the control group incidences of both tumor types average approximately 65%. In contrast, in feeding and gavage studies, control groups consistently have lower incidences of pituitary gland neoplasms (averaging 32%), and higher incidences of testis tumors (averaging nearly 90%). One hypothesis that could account for this inverse correlation is stress associated with individual housing, a protocol that is used in dermal and inhalation studies, but not in feeding and gavage studies.

除了发表更新的肿瘤发生率， 对照Fischer 344大鼠和B6C3F1小鼠，我们比较了 在NTP啮齿动物中评价的许多化学品的结果 致癌性研究和基因改变小鼠。初步 结果表明，基因改变的小鼠有可能 作为更快速和更便宜的测试系统， 致癌物质。确定了NTP数据库中的12种化学品 产生鼻腔肿瘤的肿瘤我们发现大多数鼻音 致癌物质（1）在两性中均产生肿瘤增加，（2） 在其他部位也产生肿瘤，（3）显著减少 致癌剂量下的存活率，以及（4）遗传毒性。 最后，我们发现， 对照组垂体瘤和睾丸腺瘤的发病率 雄性F344大鼠。在皮肤和吸入研究中，对照组 两种肿瘤类型的发病率平均约为65%。在 相反，在喂食和灌胃研究中，对照组始终 脑下垂体肿瘤的发病率较低（平均 睾丸肿瘤的发病率更高（平均近32%）， 90%）。有一个假设可以解释这种逆转 相关性是与个人住房相关的压力， 用于皮肤和吸入研究，但不用于喂养， 灌胃研究。