STATISTICAL ANALYSIS OF GENETIC ANALYSIS WORKSHOP 11 DATA

该项目涉及对遗传分析研讨会11的两个数据集的分析。使用连锁和关联技术分析了COGA研究酒精中毒的一组数据，找到了影响单胺氧化酶活性的一个基因座在12号染色体上可能存在连锁的证据，并表明该基因座在吸烟者中可能比不吸烟者更重要。另一组数据是关于一种极其复杂的计算机模拟特征。对忽略和试图调整环境风险因素的几种分析方法进行了比较。研究发现，如果环境风险因素对外显性有相当大的影响，则只分析暴露于风险因素的人，就可以在同胞对连锁分析中获得显著的提高。两份手稿已接受在本财政年度出版。-连锁分析、酒精中毒、模拟、样本量

This project involved analysis of two datasets from the Genetic Analysis Workshop 11. A set of data from the COGA study of alcoholism was analyzed using linkage and association techniques, finding evidence for possible linkage on chromosome 12 of a locus influencing monoamine oxidase activity and showing that this locus may be more important in smokers than in non-smokers. Another set of data was for an extremely complex computer simulated trait. Several methods of analysis both ignoring and attempting to adjust for an environmental risk factor were compared. It was found that major increases in power in sib-pair linkage analyses can be obtained by analyzing only persons exposed to the risk factor, if the environmental risk factor has a fairly large effect on penetrance. Two manuscripts have been accepted for publication in this fiscal year. - linkage analysis, alcoholism, simulation, sample size