Registration of Cardiac Ultrasound and SPECT Images

心脏超声和 SPECT 图像的配准

• 批准号: 6337706
• 负责人: FRANK P DIFILIPPO
• 金额: $ 12万
• 依托单位: ELECTROSONICS MEDICAL INC.
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-12 至 2002-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6337706
• 关键词: bioimaging /biomedical imaging; computer program /software; computer system design /evaluation; echocardiography; human data; image processing; single photon emission computed tomography

Cardiovascular disease is the most common cause of death in the western world. Diagnostic imaging of the heart through ultrasound imaging (US) and nuclear imaging (SPECT) is a valuable tool for assessing the extent of cardiac disease. Although both US and SPECT are effective modalities and are widely used, they each have limitations, and improving their effectiveness is an important goal of biomedical imaging research. Image registration techniques have been recently developed for multimodality images of various parts of the body. Since US and SPECT images provide complementary information of the heart (anatomy and function), one expects that viewing registered images would improve diagnostic efficacy. Although some cardiac image registration research has been done for other modalities, very little work has been published for US and SPECT together. In Phase I, we plan to demonstrate the feasibility of our innovative approach to US and SPECT cardiac image registration, using an automated mutual information algorithm. We will test the accuracy of the registration methods using existing clinical data, and expert clinicians will evaluate the quality of the registration. This research will lead to software tools that will improve diagnostic accuracy of cardiac imaging at minimal cost. PROPOSED COMMERCIAL APPLICATIONS: This research will lead to commercially-available software for cardiac image registration. By using standard acquisition protocols and standard file formats, we will be able to offer this software as a service to echocardiologists and nuclear cardiologists. We plan to commercialize the software on a subscription or fee-for-use basis. The existing market is rather large (over $2 billion for cardiac ultrasound and SPECT imaging), and thus even minimal market penetration will lead to commercial success.

心血管疾病是西方世界最常见的死亡原因。通过超声成像（US）和核成像（SPECT）进行的心脏诊断成像是评估心脏疾病程度的有价值的工具。虽然US和SPECT都是有效的模式，并被广泛使用，但它们都有局限性，提高其有效性是生物医学成像研究的重要目标。图像配准技术最近已经被开发用于身体的各个部分的多模态图像。由于US和SPECT图像提供了心脏的补充信息（解剖结构和功能），因此预期查看配准图像将提高诊断效率。尽管已经针对其他模式进行了一些心脏图像配准研究，但针对US和SPECT一起发表的工作很少。在第一阶段，我们计划证明我们的创新方法的可行性，美国和SPECT心脏图像配准，使用自动互信息算法。我们将使用现有的临床数据测试配准方法的准确性，专家临床医生将评估配准的质量。这项研究将导致软件工具，将提高心脏成像的诊断准确性，以最小的成本。拟议的商业应用：这项研究将导致商业可用的心脏图像配准软件。通过使用标准采集协议和标准文件格式，我们将能够将该软件作为服务提供给超声心动图专家和核心脏病专家。我们计划在订阅或收费使用的基础上将该软件商业化。现有的市场相当大（心脏超声和SPECT成像超过20亿美元），因此即使是最小的市场渗透也会导致商业上的成功。