Auto-calibrating portable low-cost micro-SPECT/CT

自动校准便携式低成本微型 SPECT/CT

• 批准号: 7280832
• 负责人: FRANK P DIFILIPPO
• 金额: $ 16.9万
• 依托单位: CLEVELAND CLINIC LERNER COM-CWRU
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-25 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7280832
• 关键词: Anatomy; Anesthesia procedures; Animal Experimentation; Animals; Applications Grants; Area; Beds; Biological Process; Calibration; Cardiology; Clinic; Clinical; Collimator; Compatible; Complex; Computer software; Count; Custom; Data; Data Analyses; Devices; Disadvantaged; Disease; Disease Progression; Equipment; Freedom; Funding; Gamma Cameras; Generations; Goals; Head; Hour; Hybrids; Image; In Vitro; Institution; Label; Laboratories; Malignant Neoplasms; Maps; Marketing; Mechanics; Methods; Modality; Modeling; Molecular; Motion; Nature; Neurology; Ocular orbit; Patients; Performance; Physiological; Positron-Emission Tomography; Procedures; Process; Radio; Range; Research; Research Institute; Research Personnel; Research Project Grants; Resolution; Rodent; Scanning; Solutions; Source; Staging; Standards of Weights and Measures; Stress; Study Section; System; Techniques; Technology; Testing; Time; Tomography, Computed, Scanners; United States National Institutes of Health; Visual; Work; attenuation; base; commercialization; cost; data acquisition; design; detector; drug discovery; image reconstruction; improved; in vivo; innovation; interest; molecular imaging; monitoring device; novel; oncology; platform-independent; pre-clinical research; programs; research study; single photon emission computed tomography; tool

DESCRIPTION (provided by applicant): We propose to develop a novel ultra-low cost portable device for micro-SPECT/CT using clinical gamma camera detectors. Molecular imaging using micro-SPECT has emerged as a valuable tool for pre-clinical research. The ability to image small animals in-vivo and non-invasively at the molecular level with spatial resolution of 1 mm or better has many research applications in cancer, molecular cardiology, neurology, and drug discovery. The importance of micro-SPECT to research is underscored by the emergence of dedicated small animal scanners in the commercial market. However, the high costs associated with these scanners have limited this technique to established and well-funded laboratories. In our previous work, we developed a practical standalone device to be used in conjunction with a clinical gamma camera. This device is placed directly on the patient table, relying on our "auto-calibration" technique (simultaneous acquisition of emission data and point source marker data) to achieve high resolution without requiring lengthy set-up time for alignment and calibration procedures. A main disadvantage was that this previous design required the animal to be rotated in a vertical orientation, which is far from ideal. Our new proposed second-generation device allows the animal to be stationary and horizontal while preserving all the low-cost advantages of a standalone device. Our preliminary experiments have demonstrated that the auto-calibration technique is robust and accurate for this new and more complex geometry. Our first aim is to design and develop this new device and characterize its micro-SPECT performance using a standard dual-head SPECT camera. Our second aim is to acquire data on a clinical SPECT/CT scanner to produce co-registered micro-SPECT and CT images. Although the CT images do not have ultra-high spatial resolution, they are sufficient for anatomic mapping and attenuation correction of the micro-SPECT data. Our third aim is to optimize the performance through improvements in count sensitivity, image reconstruction, quantitative accuracy, and ease of use. With an estimated total manufacturing cost of under $20K, and since our device is standalone, practical, and inherently compatible with nearly all models of SPECT cameras, the long-term goal of commercialization is very feasible. Many laboratories could then benefit from this device for micro-SPECT and micro-SPECT/CT.

描述(由申请人提供)：我们建议开发一种新型的超低成本便携式微型SPECT/CT设备，使用临床伽马相机探测器。使用微型SPECT的分子成像已经成为临床前研究的一个有价值的工具。以1 mm或更高的空间分辨率在分子水平上对小动物进行活体和非侵入性成像的能力在癌症、分子心脏病学、神经学和药物开发方面有许多研究应用。商业市场上出现了专门的小动物扫描仪，这突显了微型SPECT对研究的重要性。然而，与这些扫描仪相关的高昂成本限制了这项技术仅限于现有的和资金充足的实验室。在我们之前的工作中，我们开发了一种实用的独立设备，可以与临床伽马相机一起使用。该设备直接放在患者的手术台上，依靠我们的“自动校准”技术(同时采集发射数据和点源标记数据)来实现高分辨率，而不需要长时间的对准和校准过程。一个主要的缺点是，以前的设计要求动物垂直旋转，这远远不是理想的。我们新提出的第二代设备允许动物保持静止和水平，同时保留了独立设备的所有低成本优势。我们的初步实验表明，对于这一新的、更复杂的几何图形，自动校准技术是稳健和准确的。我们的第一个目标是设计和开发这种新设备，并使用标准的双头SPECT相机来表征其微SPECT性能。我们的第二个目标是获取临床SPECT/CT扫描仪的数据，以产生共同配准的微型SPECT和CT图像。虽然CT图像不具有超高的空间分辨率，但它们足以对Micro-SPECT数据进行解剖标测和衰减校正。我们的第三个目标是通过改进计数灵敏度、图像重建、定量准确性和易用性来优化性能。由于估计总制造成本不到20,000美元，而且我们的设备是独立的、实用的，并且与几乎所有型号的SPECT相机固有地兼容，因此商业化的长期目标是非常可行的。许多实验室可以从这种用于微SPECT和微SPECT/CT的设备中受益。