Lesion Detection Phantoms for Clinical and Small Animal SPECT and PET
用于临床和小动物 SPECT 和 PET 的病变检测体模
基本信息
- 批准号:7492162
- 负责人:
- 金额:$ 9.27万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2007
- 资助国家:美国
- 起止时间:2007-09-03 至 2010-08-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAffectAirAlgorithmsAnimalsCaliberCancerousChemistryClinicalComputer softwareCountDataDependenceDetectionDevelopmentDimensionsEmission-Computed TomographyError SourcesEvaluationExhibitsFacility Construction Funding CategoryFutureGoalsImageImaging PhantomsIndustryLabelLaboratory AnimalsLesionLocationManufacturer NameMeasurementMeasuresMechanicsMethodsModelingNuclearPatientsPerformancePersonal SatisfactionPhotonsPhysicsPhysiologic pulsePhysiologicalPlanning TechniquesPositron-Emission TomographyProceduresProcessPulse takingRadioRadioactiveRadioisotopesRangeRateRelative (related person)ReportingResearchResearch PersonnelResearch Project GrantsResolutionScanningShapesSimulateSolutionsSourceSpecific qualifier valueStandards of Weights and MeasuresStructureSumTestingThickTimeTomography, Computed, ScannersTracerWaterWidthWorkattenuationbasecancer imagingclinical applicationdesigndesiredetectorexperienceimage reconstructionimprovedinterestmolecular imagingnoveloncologyperformance testspre-clinicalprototyperesearch studyscale upsingle photon emission computed tomographysizestemtrendultra high resolutionuptake
项目摘要
DESCRIPTION (provided by applicant): Lesion detection is a common task in PET and SPECT cancer imaging studies. To assess scanner performance for lesion detection, phantoms with fillable hollow spheres are typically used, both for research studies and in industry standards (such as NEMA NU-2). One of the major and well-known limitations of hollow spheres phantoms is the "dead volume" associated with non-zero activity surrounding the active volume of the sphere, namely due to the sphere wall, mounting stem, and air bubbles. Because of the dead volume, a fillable sphere does not accurately represent the true clinical situation of a cancerous lesion in a background region of lesser activity concentration. For example, a hollow sphere with 10 mm internal diameter and 1.0 mm wall thickness has a wall volume that is 73% of the internal sphere volume. Our preliminary data have shown that the dead volume from a sphere of this size causes the lesion-to-background ratio to be underestimated significantly on a clinical PET scanner. Now that ultra-high resolution micro-PET and micro-SPECT scanners are commercially available, there is a need for accurate nuclear imaging phantoms with very small spheres. However, conventional phantoms are not feasible since the dead volume becomes dominant for smaller spheres, due to the cubic relationship of the wall thickness and volume. We therefore propose to develop a new variety of lesion detection phantoms that eliminate the errors from surrounding regions of non-zero activity while also being practical to use. This new design is based on the principle of superposition, where a pair of separate acquisitions is performed and the sinogram data are summed. In order for this approach to be valid, the physics underlying the two scans must be constant. Our proposed phantoms are designed to fulfill this requirement and will yield accurate results. Our aims are to develop and test a prototype full-size phantom for clinical scanners (PET and SPECT) and also a miniature version for small animal scanners (micro-PET and micro-SPECT) having spheres as small as 1.5 mm inside diameter. We will perform quantitative imaging tests to evaluate the improved accuracy in comparison to conventional phantoms. The goal of this project is to develop and test novel phantoms for performance evaluation of lesion detection in PET and SPECT oncology imaging, for both clinical scanners and pre-clinical small animal scanners. Conventional fillable spheres phantoms have a well-known limitation in that the sphere wall creates a region of zero activity ("dead volume") that significantly affects assessment of lesion detection. The proposed new design eliminates the dead volume problem and will improve clinicians' and researchers' understanding of the lesion detection capabilities of PET and SPECT scanners.
描述(申请人提供):在PET和SPECT癌症成像研究中,病变检测是一项常见的任务。为了评估用于病变检测的扫描仪性能,带有可填充中空球体的模体通常用于研究研究和行业标准(如NEMA NU-2)。中空球体模体的主要和众所周知的局限性之一是与球体活动体积周围的非零活动相关的“死体积”,即由于球体壁、安装杆和气泡。由于死亡体积,可填充球体不能准确地代表较低活度浓度背景区域中的癌症病变的真实临床情况。例如,内径10 mm、壁厚1.0 mm的中空球体的壁体积是内部球体体积的73%。我们的初步数据表明,在临床PET扫描仪上,这种大小的球体的死亡体积会导致病变与背景的比率被严重低估。现在超高分辨率的微型PET和微型SPECT扫描仪已经可以商业使用,因此需要具有非常小球体的精确核成像模体。然而,由于壁厚和体积的立方关系,对于较小的球体,死体积变得占主导地位,因此传统的体模是不可行的。因此,我们建议开发一种新的病变检测模体,它在消除周围非零活动区域的误差的同时,也具有实用价值。这种新的设计基于叠加原理,其中执行一对单独的采集并对正弦图数据求和。为了使这种方法有效,两次扫描的物理基础必须是恒定的。我们提出的模体就是为了满足这一要求而设计的,并将产生准确的结果。我们的目标是开发和测试用于临床扫描仪(PET和SPECT)的全尺寸体模原型,以及用于小型动物扫描仪(微型PET和微型SPECT)的微型版本,其球体内径小至1.5 mm。我们将进行定量成像测试,以评估与传统体模相比提高的准确性。该项目的目标是为临床扫描仪和临床前小动物扫描仪开发和测试用于PET和SPECT肿瘤学成像中病变检测性能评估的新型模体。传统的可填充球体模体有一个众所周知的局限性,即球壁产生了一个零活性区域(“死体积”),这显著影响了病变检测的评估。拟议的新设计消除了死体积问题,并将提高临床医生和研究人员对PET和SPECT扫描仪的病变检测能力的了解。
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
A fillable micro-hollow sphere lesion detection phantom using superposition.
- DOI:10.1088/0031-9155/55/18/007
- 发表时间:2010-09-21
- 期刊:
- 影响因子:3.5
- 作者:Difilippo FP;Gallo SL;Klatte RS;Patel S
- 通讯作者:Patel S
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
FRANK P DIFILIPPO其他文献
FRANK P DIFILIPPO的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('FRANK P DIFILIPPO', 18)}}的其他基金
Patient motion sensing in nuclear medicine scans
核医学扫描中的患者运动传感
- 批准号:
7690062 - 财政年份:2009
- 资助金额:
$ 9.27万 - 项目类别:
Patient motion sensing in nuclear medicine scans
核医学扫描中的患者运动传感
- 批准号:
7894823 - 财政年份:2009
- 资助金额:
$ 9.27万 - 项目类别:
Lesion Detection Phantoms for Clinical and Small Animal SPECT and PET
用于临床和小动物 SPECT 和 PET 的病变检测体模
- 批准号:
7303630 - 财政年份:2007
- 资助金额:
$ 9.27万 - 项目类别:
Auto-calibrating portable low-cost micro-SPECT/CT
自动校准便携式低成本微型 SPECT/CT
- 批准号:
7477938 - 财政年份:2006
- 资助金额:
$ 9.27万 - 项目类别:
Auto-calibrating portable low-cost micro-SPECT/CT
自动校准便携式低成本微型 SPECT/CT
- 批准号:
7280832 - 财政年份:2006
- 资助金额:
$ 9.27万 - 项目类别:
Auto-calibrating portable low-cost micro-SPECT/CT
自动校准便携式低成本微型 SPECT/CT
- 批准号:
7139850 - 财政年份:2006
- 资助金额:
$ 9.27万 - 项目类别:
A Portable Auto-Calibrating Micro-SPECT Imager
便携式自动校准微型 SPECT 成像仪
- 批准号:
6672444 - 财政年份:2003
- 资助金额:
$ 9.27万 - 项目类别:
A Portable Auto-Calibrating Micro-SPECT Imager
便携式自动校准微型 SPECT 成像仪
- 批准号:
6779883 - 财政年份:2003
- 资助金额:
$ 9.27万 - 项目类别:
Registration of Cardiac Ultrasound and SPECT Images
心脏超声和 SPECT 图像的配准
- 批准号:
6337706 - 财政年份:2001
- 资助金额:
$ 9.27万 - 项目类别:
相似海外基金
How Does Particle Material Properties Insoluble and Partially Soluble Affect Sensory Perception Of Fat based Products
不溶性和部分可溶的颗粒材料特性如何影响脂肪基产品的感官知觉
- 批准号:
BB/Z514391/1 - 财政年份:2024
- 资助金额:
$ 9.27万 - 项目类别:
Training Grant
BRC-BIO: Establishing Astrangia poculata as a study system to understand how multi-partner symbiotic interactions affect pathogen response in cnidarians
BRC-BIO:建立 Astrangia poculata 作为研究系统,以了解多伙伴共生相互作用如何影响刺胞动物的病原体反应
- 批准号:
2312555 - 财政年份:2024
- 资助金额:
$ 9.27万 - 项目类别:
Standard Grant
RII Track-4:NSF: From the Ground Up to the Air Above Coastal Dunes: How Groundwater and Evaporation Affect the Mechanism of Wind Erosion
RII Track-4:NSF:从地面到沿海沙丘上方的空气:地下水和蒸发如何影响风蚀机制
- 批准号:
2327346 - 财政年份:2024
- 资助金额:
$ 9.27万 - 项目类别:
Standard Grant
Graduating in Austerity: Do Welfare Cuts Affect the Career Path of University Students?
紧缩毕业:福利削减会影响大学生的职业道路吗?
- 批准号:
ES/Z502595/1 - 财政年份:2024
- 资助金额:
$ 9.27万 - 项目类别:
Fellowship
感性個人差指標 Affect-X の構築とビスポークAIサービスの基盤確立
建立个人敏感度指数 Affect-X 并为定制人工智能服务奠定基础
- 批准号:
23K24936 - 财政年份:2024
- 资助金额:
$ 9.27万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Insecure lives and the policy disconnect: How multiple insecurities affect Levelling Up and what joined-up policy can do to help
不安全的生活和政策脱节:多种不安全因素如何影响升级以及联合政策可以提供哪些帮助
- 批准号:
ES/Z000149/1 - 财政年份:2024
- 资助金额:
$ 9.27万 - 项目类别:
Research Grant
How does metal binding affect the function of proteins targeted by a devastating pathogen of cereal crops?
金属结合如何影响谷类作物毁灭性病原体靶向的蛋白质的功能?
- 批准号:
2901648 - 财政年份:2024
- 资助金额:
$ 9.27万 - 项目类别:
Studentship
Investigating how double-negative T cells affect anti-leukemic and GvHD-inducing activities of conventional T cells
研究双阴性 T 细胞如何影响传统 T 细胞的抗白血病和 GvHD 诱导活性
- 批准号:
488039 - 财政年份:2023
- 资助金额:
$ 9.27万 - 项目类别:
Operating Grants
New Tendencies of French Film Theory: Representation, Body, Affect
法国电影理论新动向:再现、身体、情感
- 批准号:
23K00129 - 财政年份:2023
- 资助金额:
$ 9.27万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
The Protruding Void: Mystical Affect in Samuel Beckett's Prose
突出的虚空:塞缪尔·贝克特散文中的神秘影响
- 批准号:
2883985 - 财政年份:2023
- 资助金额:
$ 9.27万 - 项目类别:
Studentship