ECAD: Enhanced Coronary Artery Disease Phantom for MRA

ECAD：MRA 增强型冠状动脉疾病模型

• 批准号: 6402326
• 负责人: THOMAS M BURKE
• 金额: $ 12.91万
• 依托单位: PHANTOMS BY DESIGN, INC
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2003-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6402326
• 关键词: angiography; bioimaging /biomedical imaging; cardiovascular function; coronary artery; coronary disorder; heart dimension /size; heart motion; model design /development; nuclear magnetic resonance spectroscopy; phantom model

Efforts to establish MRA as clinically practical are hampered by lack of realistic beating heart flow phantoms. We propose to develop an enhanced Coronary Artery Disease (eCAD) phantom for use by MR researchers and developers. eCAD combines features from existing technologies with advanced design, materials and processing to create a controlled environment which reproduces clinical conditions. This will be accomplished by: 1) developing functional cardiac structures based on image data, 2) combining structures with advanced materials and processing to reproduce cardiac functionality and 3) establishing proof- of-concept by verifying that eCAD is anatomically accurate with proper flow patterns and motion under pulsatile conditions. Innovative aspects include designs based on clinical image information, tissue mimicking materials compatible with MRI characteristics, realistic motion of cardiac wall and coronary arteries, and reliability exceeding one year. Technology developed in Phase I will support the additional cardiac structures and variable wall elasticity. In Phase II, we focus on optimizing component materials and procedures in anticipation of constructing advanced flow phantoms for Phase III clinical trials. A commercially available eCAD will be critical for the development, validation and training of medical personnel on using state of the art MRA diagnostic protocols for coronary artery disease. PROPOSED COMMERCIAL APPLICATIONS: The magnitude of the clinical need for a non invasive means to identify patients at risk and stage coronary artery surgery is so large and the commercial availability of adequate MRI tools so limited as to create a lucrative market niche for highly advanced anthropomorphic flow phantoms targeted at coronary artery disease. Products developed from this project will address current and future needs in clinical research, QA, and personnel training applications.

由于缺乏真实的搏动心流模型，MRA 在临床上的实用性受到了阻碍。我们建议开发一种增强型冠状动脉疾病 (eCAD) 模型，供 MR 研究人员和开发人员使用。 eCAD 将现有技术的功能与先进的设计、材料和加工相结合，创建一个可重现临床条件的受控环境。这将通过以下方式实现：1) 基于图像数据开发功能性心脏结构，2) 将结构与先进材料和处理相结合以再现心脏功能，3) 通过验证 eCAD 在解剖学上的准确性以及脉动条件下的正确流动模式和运动来建立概念验证。创新方面包括基于临床图像信息的设计、与MRI特性兼容的组织模拟材料、心壁和冠状动脉的真实运动以及超过一年的可靠性。第一阶段开发的技术将支持额外的心脏结构和可变的壁弹性。在第二阶段，我们专注于优化组件材料和程序，以期为第三阶段临床试验构建先进的流动体模。商用 eCAD 对于医务人员使用最先进的 MRA 冠状动脉疾病诊断方案的开发、验证和培训至关重要。拟议的商业应用：临床上对一种非侵入性手段来识别有风险的患者并对其进行分期冠状动脉手术的需求量如此之大，而足够的 MRI 工具的商业可用性却如此有限，以至于为针对冠状动脉疾病的高度先进的拟人流动体模创造了一个利润丰厚的市场利基。该项目开发的产品将满足临床研究、质量保证和人员培训应用中当前和未来的需求。