ECAD:Enhanced Coronary Artery Disease Phantom for MRA

ECAD：MRA 增强型冠状动脉疾病模型

• 批准号: 6836069
• 负责人: THOMAS M BURKE
• 金额: $ 37.89万
• 依托单位: PHANTOMS BY DESIGN, INC
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6836069
• 关键词: angiography; bioimaging /biomedical imaging; clinical research; computer program /software; computer system design /evaluation; computer system hardware; coronary disorder; digital imaging; hemodynamics; human data; magnetic resonance imaging; model design /development; morphology; myocardium; phantom model; physical model; pulmonary respiration; technology /technique development

DESCRIPTION (provided by applicant): Efforts to establish MRA as clinically practical are hampered by lack of realistic beating heart flow phantom. We propose to develop an enhanced Coronary Artery Disease (eCAD) phantom for use by MR researchers, developers and medical equipment manufacturers, eCAD combines advanced features from previously introduced technology with innovative design, materials and processing to create a controlled environment which reproduces clinical conditions. This will be accomplished by: 1) developing functional cardiac structures based on clinical data, 2) combining structures with advanced materials, processing and modular infrastructure to reproduce cardiac functionality, 3) verifying eCAD is anatomically accurate with proper flow patterns and motion under pulsatile flow conditions and 4) demonstrating prototype reproducibility, stability and commercial potential during extended evaluations in academic and industrial environments. Design optimization and manufacturing technologies are significantly improved through the introduction of powerful computer based, finite element analysis and CAD/CAM integration with in house CNC prototype hardware. Process technology improvements will assist Phase Ill commercialization. A commercially available eCAD will be critical for the development, validation and training of medical personnel on using state of the art MRA diagnostic protocols for coronary artery disease.

描述（由申请人提供）：