Enhanced carotid bifurcation phantom for MRI/A

描述(申请人提供)：颈动脉的无创性MRI评估 动脉壁管腔和血流模式因缺乏 全面和解剖正确的商业可用的流动体模。这个 该项目的目标是开发一种先进的人工颈动脉 用于开发MRI应用程序以识别患者的流动体模 短暂性脑缺血发作或中风的风险。在第一阶段，概念验证是 已经成立了。选择第二阶段的技术目标，以系统地扩展 关键技术的知识和经验基础：1)管腔设计，基于 图像数据，2)壁面力学，具有区域变化，3)图像形态， 包括两层不同的纤维帽病变和4)液体运动 定制脉动流量泵及其与血流动力学实验结果的比较 模拟。原型的构建和评估涉及：学术、临床 和工业环境，以衡量商业潜力并确定关键 商业开发的功能要求。原料和制剂 进行了优化，以获得参数的精度和稳定性。 在18个月内增长20%。一个全面的流程体模将对 医务人员使用状况的开发、验证和培训 动脉粥样硬化性颈动脉疾病的artmri筛查方案。 建议的商业应用： 临床上需要一种非侵入性手段来识别有风险的患者并进行颈动脉手术，这一需求是如此之大，而足够的MRI工具的商业可用性如此有限，以至于为针对脑血管疾病的高度先进的拟人血流模型创造了一个有利可图的利基市场。通过该项目开发的产品将满足临床研究、质量保证和人员培训应用程序的当前和未来需求。(参见产品开发计划，第45-50页)。

DESCRIPTION (provided by applicant): Non invasive MRI evaluation of the carotid artery wall lumen and blood flow patterns is hampered by the lack of a comprehensive and anatomically correct commercially available flow phantom. The objective of this project is to develop an advanced artificial carotid artery flow phantom for use in developing MRI applications to identify patients at risk for transient ischemic attack or strokes. In Phase I, proof-of-concept was established. Phase II technical aims are selected to systematically expand the knowledge and experience base of key technologies: 1) lumen design, based on image data, 2) wall mechanics, with regional variation, 3) image morphology, including two distinct layers with fibrous cap lesion and 4) fluid motion with custom pulsatile flow pump and experimental results compared to hemodynamic simulations. Prototypes are constructed and evaluated in: academic, clinical and industrial environments to gauge commercial potential and identify key functional requirements for commercial development. Materials and preparations are optimized to obtain precision and stability of parameters on the order of 20 percent over 18 months. A comprehensive flow phantom will be critical for the development, validation and training of medical personnel on using state of the art MRI screening protocols for atherosclerotic carotid artery disease. PROPOSED COMMERCIAL APPLICATION: The magnitude of the clinical need for a non invasive means to identify patients at risk and stage carotid artery surgery is so large and the commercial availability of adequate MRI tools so limited as to create a lucrative market niche for highly advanced anthropomorphic flow phantoms targeted at cerebrovascular disease. Products developed from this project will address current and future needs in clinical research, QA, and personnel training applications. (See Product Development Plan, pages 45-50).