ECAD:Enhanced Coronary Artery Disease Phantom for MRA

ECAD：MRA 增强型冠状动脉疾病模型

• 批准号: 6990547
• 负责人: THOMAS M BURKE
• 金额: $ 19.35万
• 依托单位: PHANTOMS BY DESIGN, INC
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6990547
• 关键词: angiography; bioimaging /biomedical imaging; clinical research; computer program /software; computer system design /evaluation; computer system hardware; coronary disorder; digital imaging; hemodynamics; human data; magnetic resonance imaging; model design /development; morphology; myocardium; phantom model; physical model; pulmonary respiration; technology /technique development

DESCRIPTION (provided by applicant): Efforts to establish MRA as clinically practical are hampered by lack of realistic beating heart flow phantom. We propose to develop an enhanced Coronary Artery Disease (eCAD) phantom for use by MR researchers, developers and medical equipment manufacturers, eCAD combines advanced features from previously introduced technology with innovative design, materials and processing to create a controlled environment which reproduces clinical conditions. This will be accomplished by: 1) developing functional cardiac structures based on clinical data, 2) combining structures with advanced materials, processing and modular infrastructure to reproduce cardiac functionality, 3) verifying eCAD is anatomically accurate with proper flow patterns and motion under pulsatile flow conditions and 4) demonstrating prototype reproducibility, stability and commercial potential during extended evaluations in academic and industrial environments. Design optimization and manufacturing technologies are significantly improved through the introduction of powerful computer based, finite element analysis and CAD/CAM integration with in house CNC prototype hardware. Process technology improvements will assist Phase Ill commercialization. A commercially available eCAD will be critical for the development, validation and training of medical personnel on using state of the art MRA diagnostic protocols for coronary artery disease.

描述（由申请人提供）： 由于缺乏真实的搏动心流模型，MRA 在临床上的实用性受到了阻碍。我们建议开发一种增强型冠状动脉疾病 (eCAD) 模型，供 MR 研究人员、开发人员和医疗设备制造商使用，eCAD 将先前引入的技术的先进功能与创新设计、材料和处理相结合，创建一个可重现临床状况的受控环境。这将通过以下方式实现：1) 基于临床数据开发功能性心脏结构，2) 将结构与先进材料、处理和模块化基础设施相结合以重现心脏功能，3) 验证 eCAD 在解剖学上是否准确，并在脉动流条件下具有正确的流动模式和运动，4) 在学术和工业环境中的扩展评估过程中展示原型的再现性、稳定性和商业潜力。通过引入强大的基于计算机的有限元分析以及 CAD/CAM 与内部 CNC 原型硬件的集成，设计优化和制造技术得到显着改进。工艺技术的改进将有助于第三阶段的商业化。商用 eCAD 对于医务人员使用最先进的 MRA 冠状动脉疾病诊断方案的开发、验证和培训至关重要。