ATHEROSCLEROTIC LESION PHANTOM (ALP) FOR MRI/A

描述（申请人摘要逐字）：MRI技术的发展， 针对心血管疾病（CVD）应用进行了优化， 低信噪比（SNR）、组织运动和血流伪影。 本项目的长期目标是开发一种动脉粥样硬化病变 体模（ALP），以协助MRI社区开发非侵入性应用， 识别有临床急性CV综合征风险的患者。这将是 通过以下方式实现：1）准确地建模关键致病菌的形态 与高风险动脉粥样硬化病变相关的特征和2）提供 控制环境，再现与 临床影像学ALP结合了现有技术的优势： 创新的人造动脉，包括多个壁层（Aim 1），狭窄 模拟以下病变的形态（Aim 2）和MRI内容（T1，T2，对比度）的病变 动脉粥样硬化病变的稳定和良好的表征方式（目的3）。在 第二阶段，我们专注于优化第一阶段确定的材料和程序 为三期产品建设先进的流动模型 评价一个全面的ALP将是发展的关键， 验证新的临床应用以及培训医疗 使用最先进的MRI筛查方案进行动脉粥样硬化 CVD。 拟定商业应用： 临床上对非侵入性方法的需求量，以确定患者的风险， 斑块破裂或侵蚀是如此之大， 如此有限，以至于为高度晚期动脉粥样硬化病变创造了有利可图的市场利基 针对心血管疾病的体模。 该项目开发的产品将 满足临床研究、质量保证和人员培训的当前和未来需求 应用.

DESCRIPTION (Applicant's abstract verbatim): Development of MRI techniques, optimized for cardiovascular disease (CVD) applications, are currently hampered by low signal to noise ratios (SNR), tissue motion and blood flow artifacts. The long term goal of this project is to develop an Atherosclerotic Lesion Phantom (ALP) to assist the MRI community develop non invasive applications to identify patients at risk for clinically acute CV syndromes. This will be accomplished by: 1) accurately modeling the morphology of key pathogenic features associated with high risk atherosclerotic lesions and 2) providing a controlled environment that reproduces the difficulties associated with clinical imaging. ALP combines the benefits of existing technologies with: an innovative artificial artery including multiple wall layers (Aim 1), stenotic lesions that mimic the morphology (Aim 2) and MRI content (T1, T2, contrast) of atherosclerotic lesions in a stable and well characterized manner (Aim 3). In Phase II, we focus on optimizing materials and procedures identified in Phase I in anticipation of constructing advanced flow phantoms for Phase III product evaluation. A comprehensive ALP will be critical for the development and validation of new clinical applications as well as in training medical personnel on using state of the art MRI screening protocols for atherosclerotic CVD. PROPOSED COMMERCIAL APPLICATION: The magnitude of the clinical need for a non invasive means to identify patients at risk for plaque rupture or erosion is so large and the commercial availability of adequate MRI tools so limited as to create a lucrative market niche for a highly advanced atherosclerotic lesion phantom targeted at cardiovascular disease. Products developed from this project will address current and future needs in clinical research, QA, and personnel training applications.