Slipstream Visualization Technology for MRI/A Phantoms

MRI/A 体模的滑流可视化技术

• 批准号: 6630710
• 负责人: THOMAS M BURKE
• 金额: $ 11.76万
• 依托单位: PHANTOMS BY DESIGN, INC
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-04-07 至 2004-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6630710
• 关键词: bioimaging /biomedical imaging; blood flow measurement; capillary bed; computer program /software; computer system hardware; digital imaging; fluid flow; hemodynamics; magnetic resonance imaging; model design /development; phantom model; video recording system

DESCRIPTION (provided by applicant): Development of noninvasive MRI applications to simultaneously evaluate cardiovascular anatomy and flow dynamics is hampered by the lack of relevant commercial flow phantoms. Previously, innovative technology was developed to produce enhanced carotid bifurcation and coronary artery phantoms with design based on image data, realistic wall mechanics and branching secondary vessels. We propose to extend these capabilities to include enhancement of local flow dynamics associated with: 1) lumen wall features linked to clinical risk and 2) regionally impaired coronary flow. This will be accomplished by first developing a gated fluid delivery system (FDS) (Aim 1). Then exploiting FDS capabilities for: 1) slipstream visualization technology (SVT) and 2) quantitative vascular bed flow (VBF) (Aim2). Proof-of-concept is established for 1) SVT by documenting slipstream visualization optically and in real-time MR flow images with results compared to advanced CFD simulations and 2) VBF by delivering multiple defined volumes of coronary flow with regional variations for coronary reserve studies (Aim 3). Results and issues are documented and pathways to improved functionality and ergonomics are identified for Phase II (Aim 4). Combined visualization of anatomic and flow (measured & simulated) provides critical information not currently available for model validation and application development.

描述（由申请人提供）： 由于缺乏相关的商业流动体模，同时评估心血管解剖学和血流动力学的无创 MRI 应用的开发受到阻碍。此前，我们开发了创新技术来生产增强型颈动脉分叉和冠状动脉模型，其设计基于图像数据、真实的壁力学和分支的次级血管。我们建议扩展这些功能，包括增强与以下相关的局部血流动力学：1）与临床风险相关的管腔壁特征和2）局部冠状动脉血流受损。这将通过首先开发门控流体输送系统 (FDS) 来实现（目标 1）。然后利用 FDS 功能：1) 滑流可视化技术 (SVT) 和 2) 定量血管床流量 (VBF)（目标2）。概念验证的建立是为了 1) SVT，通过光学记录滑流可视化和实时 MR 血流图像，并将结果与​​先进的 CFD 模拟进行比较；2) VBF，通过提供多个定义的冠状动脉流量以及冠状动脉储备研究的区域变化（目标 3）。记录结果和问题，并确定第二阶段（目标 4）改进功能和人体工程学的途径。解剖和流动（测量和模拟）的组合可视化提供了当前无法用于模型验证和应用程序开发的关键信息。