EFFECTS OF BEDREST ON FOREARM MUSCLE REFLEXES

卧床休息对前臂肌肉反射的影响

• 批准号: 6123171
• 负责人: Lawrence I Sinoway
• 金额: $ 3.26万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6123171
• 关键词: clinical research; exercise; human subject; imaging /visualization /scanning; mechanoreceptors; muscle contraction; nuclear magnetic resonance spectroscopy; reflex; restricted physical activity; sympathetic nervous system

The overall objectives of this project are to examine the effects of 2 weeks of bed rest on the sympathetic nerve responses to rhythmic and static forearm exercise. We postulate that sympathetic nerve responses will be increased because lactic acid production and forearm interstitial volume will be increased. We further postulate that forearm handgrip exercise and/or intermittant forearm compression will act as countermeasures to obviate the effects of bedrest. In the first year of the project, we will examine the effects of bedrest on the sympathetic nerve responses to: static exercises, rythmic forearm exercise and involuntary biceps contraction. Since increases in sympathetic discharge during static exercise are predominantly due to excitation of metaboreceptors, the experiments in static exercise will help determine if metaboreceptor activity is enhanced by bedrest. Experiments in rhythmic forearm exercise will be performed to examine whether mechanorecptor activity and/or central command activity is augmented by bedrest. The experiments in involuntary bicep contraction will be performed to determine whether mechanically-sensitive afferents in the human forearm are sensitized by the 2 week period of bedrest. State of the art human physiology techniques including microneurography and NMR will be used.

本研究的主要目的是探讨卧床休息2周对交感神经对前臂节律性运动和静态运动的反应。 我们推测，交感神经反应将增加，因为乳酸的生产和前臂间质体积将增加。 我们进一步假设，前臂握力练习和/或不情愿的前臂压迫将作为对抗措施，以消除卧床休息的影响。 在第一年的计画中，我们将检视卧床对交感神经反应的影响：静态运动、有节奏的前臂运动和不自主的二头肌收缩。 由于静态运动期间交感神经放电的增加主要是由于代谢受体的兴奋，静态运动中的实验将有助于确定卧床休息是否会增强代谢受体的活性。 将进行有节奏的前臂运动实验，以检查机械感受器活动和/或中央命令活动是否通过卧床休息而增强。 将进行二头肌不自主收缩的实验，以确定人前臂中的机械敏感传入神经是否被2周的卧床时间敏化。 将使用最先进的人体生理学技术，包括显微神经造影术和NMR。