PLANNING GRANT FOR MULTIPURPOSE CRCS

多用途 CRCS 规划拨款

• 批准号: 6076193
• 负责人: RICHARD A. GALBRAITH
• 金额: $ 15.06万
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-30 至 2002-03-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6076193
• 关键词: health science research potential; interdisciplinary collaboration; musculoskeletal disorder

The goal of this P20 Planning Grant Application from the University of Vermont is to build the infrastructure to support the intellectual interactions that will lead to a collaborative multidisciplinary clinical research program focusing on musculoskeletal function and dysfunction. The overall goal is to compete for a P60 Multipurpose Clinical Research Center Award. The University of Vermont and its affiliated teaching hospital, Fletcher Allen Health Care, has a wide range of successful, funded investigators working in basic, translational and clinical research fields with an emphasis on musculoskeletal disease. In addition, being the only tertiary health care facility in the State of Vermont, there are adequate numbers of patients with diseases which fall within the purvue of NIAMS and there is a past history of willingness of patients to enroll in and complete clinical research trials at the General Clinical Research Center and elsewhere in the outpatient system. The application details this research base and the supporting resources and existing Centers which will augment and foster the kinds of clinical research projects which will be included in the P60 application. The application also details the infrastructure which will be established to achieve these goals and our plans for the use of Internal and External Advisory Committees and the prominent role of the Biostatistics/Research Core. Finally, the application also includes examples of the kinds of interactions and synergies which have already arisen from the discussions of interested investigators. Examples include, but are not limited to, magnetic resonance imaging and outcomes studies to assess factors which lead to osteoarthritis of the knee following partial meniscectomy; the synergistic addition of studies of neuromuscular control to biomechanical studies in acute back injuries and ankle sprains; the application of basic science studies to determine maximal shortening velocity of muscle fibers, myosin and actin force and interaction, and mitochondrial function and DNA mutations in patients who have fibromyalgia syndrome; the use of an experimental dense multichannel EMG array in conjunction with real-time ultrasound imaging to gain a better understanding of the etiology of idiopathic low back pain; and studies of the interactions between eccentric exercise, muscle damage and postural stability with a view to reducing falls in the elderly and studying chronic musculoskeletal conditions such as rheumatoid arthritis and disuse atrophy. These or other examples could be further refined and expanded if this application were successful and where appropriate, the resources of the existing NIH-funded General clinical Research Center could be leveraged to perform resulting clinical research and outcomes projects.

佛蒙特大学 P20 规划拨款申请的目标是建立支持智力互动的基础设施，从而形成专注于肌肉骨骼功能和功能障碍的协作性多学科临床研究项目。 总体目标是争夺 P60 多用途临床研究中心奖。佛蒙特大学及其附属教学医院 Fletcher Allen Health Care 拥有众多成功的、受资助的研究人员，从事基础、转化和临床研究领域，重点关注肌肉骨骼疾病。 此外，作为佛蒙特州唯一的三级医疗机构，NIAMS 拥有足够数量的疾病患者，并且过去有患者愿意在普通临床研究中心和门诊系统其他地方参加并完成临床研究试验的历史。 该申请详细介绍了该研究基地以及支持资源和现有中心，这些中心将扩大和培育将包含在 P60 申请中的临床研究项目类型。该申请还详细介绍了为实现这些目标而建立的基础设施、我们使用内部和外部咨询委员会的计划以及生物统计/研究核心的突出作用。 最后，该应用程序还包括从感兴趣的研究人员的讨论中已经出现的相互作用和协同作用类型的示例。 例子包括但不限于磁共振成像和结果研究，以评估部分半月板切除术后导致膝关节骨关节炎的因素；将神经肌肉控制研究与急性背部损伤和踝关节扭伤的生物力学研究相结合；应用基础科学研究来确定纤维肌痛综合征患者的肌纤维最大缩短速度、肌球蛋白和肌动蛋白力及其相互作用、线粒体功能和 DNA 突变；使用实验性密集多通道肌电图阵列与实时超声成像相结合，更好地了解特发性腰痛的病因；研究离心运动、肌肉损伤和姿势稳定性之间的相互作用，以减少老年人跌倒，并研究类风湿性关节炎和废用性萎缩等慢性肌肉骨骼疾病。 如果该应用成功，并且在适当的情况下，可以利用 NIH 资助的现有普通临床研究中心的资源来执行由此产生的临床研究和成果项目，可以进一步完善和扩展这些或其他示例。