RISK OF OSTEOPOROSIS IN PATIENTS WITH RECENT ONSET SYSTEMIC LUPUS ERYTHMATOSUS

系统性红斑狼疮是一种慢性炎症性自身免疫性疾病，以病情恶化和缓解为特征。最不可预测的病程最有可能发生在疾病的头几年。初步证据表明，红斑狼疮患者骨密度降低的频率增加。狼疮患者骨密度低的原因尚不清楚。我们将调查假说，即在发病的头两年骨丢失加速，并且这种骨丢失与狼疮疾病及其治疗(狼疮疾病活动性、炎症介质水平和/或类固醇负担)有关。这是一项针对30名病程不到2年的狼疮患者的先导性纵向研究。具体目的是：1)测量基线和随访一年后的骨密度(BMD)；2)估计骨密度在一年内的变化率；3)分析一年中每三个月测量一次的狼疮疾病活动、炎症介质和类固醇负荷与骨密度和骨密度变化的关系；四)探讨一年中每三个月测量一次的狼疮疾病活动、炎症介质和类固醇负荷与骨形成和骨吸收的生化指标的关系。

SLE is a chronic, inflammatory, autoimmune disease characterized by exacerbations and remissions. The most unpredictable disease course is most likely to occur during the first few years of the illness. Preliminary evidence has documented an increased frequency of low bone mineral density in women with lupus. The reasons for low BMD in lupus patients are unclear. We will investigate the hypotheses that bone loss is accelerated during the first two years of disease onset and that this loss of bone is related to lupus disease and its treatment (lupus disease activity, levels of inflammatory mediators, and/or steroid burden). This is a pilot, longitudinal study of 30 patients with lupus of less than 2 years duration. The specific aims are: 1) to measure bone mineral density (BMD) at baseline and after one year of follow up, 2) to estimate the rate of change in bone mineral density over one year, 3) to analyze the relationships of lupus disease activity, inflammatory mediators, and steroid burden measured every three months over the course of one year with BMD and change in BMD, and 4) to explore the relationships of lupus disease activity, inflammatory mediators, and steroid burden measured every three months over the course of one year with biochemical markers of bone formation and bone resorption.