EPIDEMIOLOGY OF OSTEOPOROSIS IN WOMEN WITH LUPUS

狼疮女性骨质疏松症的流行病学

• 批准号: 6114085
• 负责人: Rosalind Ramsey-Goldman
• 金额: $ 2.05万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6114085
• 关键词: African American; biomarker; bone density; bone fracture; caucasian American; clinical research; comorbidity; corticosteroids; disease /disorder proneness /risk; epidemiology; female; hormone therapy; human subject; osteoporosis; racial /ethnic difference; systemic lupus erythematosus; women's health

The specific aims to be addressed in this study are: 1) To estimate the prevalence of subclinical bone disease in Caucasian and African-American women with lupus; 2) To determine the association between low bone mass and bone biochemical markers, SLE-related risk factors, and traditional osteporosis risk factors in Caucasian and African-American women with lupus; and 3) To document prospectively the rate of fracture in Caucasian and African-American women with lupus. The hypotheses to be examined in this study are: 1) There is a high prevalence of subclnical bone disease (low bone mass) and clinical bone disease (fractures) in Caucasian and African-American women with lupus; 2) Low bone mass and fractures in Caucasian and African-American women with lupus are due to an interaction between iflammation-induced alterations in bone architecture from the underlying disease and traditional risk factors (such as early menopause and avoidance of estrogen replacement therapy); and 3) Corticosteroid treatment accelerates the loss of bone in both Caucasian and African-American women with lupus.

本研究的具体目的是：1)估计高加索和非裔美国狼疮妇女亚临床骨病的患病率；2)探讨白人和非裔美国狼疮女性低骨量与骨生化指标、sle相关危险因素及传统骨质疏松危险因素的关系；3)前瞻性地记录白人和非裔美国狼疮妇女的骨折率。本研究的假设是：1)白人和非裔美国狼疮女性的亚临床骨病（低骨量）和临床骨病（骨折）患病率较高；2)白人和非裔美国狼疮妇女的低骨量和骨折是由于潜在疾病引起的炎症引起的骨结构改变和传统危险因素（如早期绝经和避免雌激素替代治疗）之间的相互作用；3)皮质类固醇治疗加速了白种人和非裔美国狼疮妇女的骨质流失。