ACTH STIMULATION TEST TO EVALUATE ADEQUACY OF HPA AXIS

ACTH 刺激试验评估 HPA 轴的充足性

• 批准号: 6264128
• 负责人: ROY E WEISS
• 金额: $ 3.28万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6264128
• 关键词: Cushing's syndrome; adenoma; adrenocorticotropic hormone; clinical research; diagnosis quality /standard; endocrine disorder diagnosis; endocrine surgery; hormone biosynthesis; human subject; hypothalamic pituitary adrenal axis; medical complication; postoperative state

This study will compare the sensitivity of the 1 mcg ACTH stimulation test to gold standard insulin tolerance testing in determining hypothalamic- pituitary-adrenal recovery in patients status post surgery for Cushing's syndrome secondary to pituitary or adrenal adenomas. These two tests will also be compared in patients with suspected hypopituitarism, to determine the ACTH test's sensitivity in screening for dysfunction. If the ACTH test has sufficient sensitivity, it could replace the insulin test in clinical practice.

这项研究将比较1 MCG ACTH刺激测试的敏感性与金标准胰岛素耐受性测试，以确定在手术后患者的下丘脑 - 垂体 - 肾上腺肾上腺恢复的cushing综合征，继发于垂体或肾上腺腺瘤。 还将比较这两项测试的疑似肌次症患者，以确定ACTH测试在筛查功能障碍中的敏感性。 如果ACTH测试具有足够的敏感性，则可以在临床实践中取代胰岛素测试。