KUMETRIX INC

库美特里克斯公司

• 批准号: 6360889
• 负责人: Wilson Harvey Smart
• 金额: $ 10万
• 依托单位: KUMETRIX, INC.
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-29 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6360889
• 关键词: bioengineering /biomedical engineering; biomedical equipment development; biosensor device; blood glucose; consumable /disposable biomedical equipment; electrochemistry; micromanipulator; miniature biomedical equipment; patient monitoring device; silicon

This project will combine recent advances in electrochemical biosensor technology achieved in many laboratories with unique silicon microprobe technology developed in our laboratory, to produce low cost disposable biosensor microprobes for painless continuous measurement of blood glucose concentration. Impressive glucose biosensor R&D progress has not yet resulted in commercial devices for painless in vivo applications because other workers in "needle biosensors" have used conventional configurations and fabrication methods. The high cost and size (hypodermic needle diameters, requiring painful surgical implantation) of conventional biosensors requires that they last a long time. The principal approach taken by others to make them practical is to extend their lifetimes toward six months of operation, but this effort has produced only slow incremental progress. The strength of the proposed approach lies in the combination of biosensors and silicon microprobes. By rendering insertion and removal completely painless (which has been shown in clinical trials) and sharply reducing the cost, disposable integrated biosensor microprobes employing electrochemical sensor technology at its present state of development become commercially practical. Integration of biosensors with silicon microprobes comparable in cross-section to a human hair to provide a practical technique for painless blood testing is not restricted to glucose but is an enabling technology applicable to many other analytes.

该项目将结合联合收割机在许多实验室取得的电化学生物传感器技术的最新进展与我们实验室开发的独特的硅微探针技术，生产低成本的一次性生物传感器微探针，用于无痛连续测量血糖浓度。 令人印象深刻的葡萄糖生物传感器研发进展尚未导致用于无痛体内应用的商业设备，因为“针式生物传感器”的其他工作人员使用传统的配置和制造方法。 传统生物传感器的高成本和尺寸（皮下注射针直径，需要痛苦的外科植入）要求它们持续很长时间。 其他人为使其实用化而采取的主要办法是将其使用寿命延长到6个月，但这一努力只取得了缓慢的渐进进展。 所提出的方法的优势在于生物传感器和硅微探针的组合。 通过使插入和移除完全无痛（这已在临床试验中显示）并大幅降低成本，采用电化学传感器技术的一次性集成生物传感器微探针在其目前的发展状态下变得商业实用。 将生物传感器与硅微探针集成，其横截面与人的头发相当，以提供用于无痛血液检测的实用技术，并不限于葡萄糖，而是适用于许多其他分析物的使能技术。