GENTLE METHOD OF PHLEBOTOMY AND ASSAY

温和的放血和检测方法

• 批准号: 6163781
• 负责人: Wilson Harvey Smart
• 金额: $ 37.83万
• 依托单位: KUMETRIX, INC.
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-15 至 2001-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6163781
• 关键词: biomedical equipment development; blood chemistry; clinical biomedical equipment; hypodermic needle; mechanical stress; method development; phlebotomy

Skin fragility and a tendency to excessive bleeding among older people impose special problems in drawing routine blood samples. The design of the blood sampling and assay system described here addresses these problems by using an integrated needle and microcuvette consumable to draw a sample of less than one microliter and perform the assay with this volume. During Phase I, experimental consumable of this design will be made by silicon microfabrication technology and evaluated in needed strength tests and glucose assays. Devices differing in the outside diameter, bore, wall thickness, and length of the needle will be made. The key aim is to obtain a correlation between the strength of the needle and these mechanical parameters. A subsidiary aim is to demonstrate a glucose assay with whole blood in consumables of this design. Consumables with favorable combinations of properties, as determined by these tests, will then be fabricated and tested. In this iterative manner, the development program intends to progress toward consumables having such fine needles (less than 100 micrometer diameter) that the sampling process is likely to be nearly painless. Further development of this novel technology offers the benefits of painlessness, sub-microliter sample volume, immediacy of the result, low cost, ease of use, and ability to assay many analyses. PROPOSED COMMERCIAL APPLICATION: The blood testing product that will emerge from this development program will be of particular benefit to the older patient population because of its lack of pain, minimal tissue damage, and small sample volume. In addition, its ease of use makes it attractive for home health care, nursing homes, and self testing.

老年人的皮肤脆弱和出血过多的倾向 在抽取常规血样时遇到特殊问题。一种新的设计 这里描述的血液采样和化验系统解决了这些问题 使用一体式针头和微量试管耗材进行绘图的问题 一份少于一微升的样本，用这个进行化验 音量。在第一阶段，该设计的实验消耗品将是 由硅微制造技术制造，并在需要时进行评估 强度测试和血糖检测。外观不同的设备 将制作针的直径、孔、壁厚和长度。 关键的目标是获得针的强度之间的相关性 以及这些力学参数。一个次要目标是展示一个 本设计耗材中的全血葡萄糖测定法。消耗品 如这些测试所确定的，具有良好的性能组合， 然后将被制造和测试。在这种迭代方式中， 开发计划打算朝着拥有这样的消耗品的方向发展 细针(直径小于100微米)即取样过程 很可能几乎是无痛的。这部小说的进一步发展 技术提供了无痛、亚微升样本的好处 体积、结果的即时性、低成本、易用性和能力 分析了许多分析。 建议的商业应用：血液检测产品将 从这一发展计划中脱颖而出将特别有利于 老年患者群体，因为它没有疼痛，组织最少 损伤大，样品体积小。此外，它的易用性使它成为 对家庭保健、疗养院和自我测试具有吸引力。