GENTLE METHOD OF PHLEBOTOMY AND ASSAY

温和的放血和检测方法

• 批准号: 2422812
• 负责人: Wilson Harvey Smart
• 金额: $ 10万
• 依托单位: KUMETRIX, INC.
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-15 至 1998-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2422812
• 关键词: biomedical equipment development; blood chemistry; clinical biomedical equipment; hypodermic needle; mechanical stress; method development; phlebotomy

Skin fragility and a tendency to excessive bleeding among older people impose special problems in drawing routine blood samples. The design of the blood sampling and assay system described here addresses these problems by using an integrated needle and microcuvette consumable to draw a sample of less than one microliter and perform the assay with this volume. During Phase I, experimental consumable of this design will be made by silicon microfabrication technology and evaluated in needed strength tests and glucose assays. Devices differing in the outside diameter, bore, wall thickness, and length of the needle will be made. The key aim is to obtain a correlation between the strength of the needle and these mechanical parameters. A subsidiary aim is to demonstrate a glucose assay with whole blood in consumables of this design. Consumables with favorable combinations of properties, as determined by these tests, will then be fabricated and tested. In this iterative manner, the development program intends to progress toward consumables having such fine needles (less than 100 micrometer diameter) that the sampling process is likely to be nearly painless. Further development of this novel technology offers the benefits of painlessness, sub-microliter sample volume, immediacy of the result, low cost, ease of use, and ability to assay many analyses. PROPOSED COMMERCIAL APPLICATION: The blood testing product that will emerge from this development program will be of particular benefit to the older patient population because of its lack of pain, minimal tissue damage, and small sample volume. In addition, its ease of use makes it attractive for home health care, nursing homes, and self testing.

老年人皮肤脆弱且容易出血过多 在抽取常规血样时存在特殊问题。 的设计 这里描述的血液采样和分析系统解决了这些问题 使用集成针和微量比色皿消耗品进行绘制时出现的问题 少于一微升的样品并用此进行测定 体积。 在第一阶段，该设计的实验耗材将是 采用硅微加工技术制造并根据需要进行评估 力量测试和葡萄糖测定。 设备外观不同 将制作针的直径、孔径、壁厚和长度。 主要目的是获得针强度之间的相关性 以及这些机械参数。 一个附属目标是展示 在这种设计的耗材中用全血进行葡萄糖测定。 耗材 通过这些测试确定具有良好的性能组合， 然后将被制造和测试。 通过这种迭代方式， 开发计划旨在向具有此类功能的消耗品迈进 细针（直径小于100微米）表示取样过程 可能几乎是无痛的。 这部小说的进一步发展 技术提供无痛、亚微升样品的优点 体积大、结果即时、成本低、易于使用以及能够 进行许多分析。 拟议的商业应用：血液检测产品将 这项发展计划的出现将特别有利于 老年患者群体因为缺乏疼痛、组织最少 损坏，样品量小。 此外，它的易用性使其 对于家庭医疗保健、疗养院和自我测试很有吸引力。