SUB-MICROLITER ELECTROCHEMICAL ASSAY FOR BLOOD GLUCOSE

亚微升电化学测定血糖

• 批准号: 6211105
• 负责人: Wilson Harvey Smart
• 金额: $ 10万
• 依托单位: KUMETRIX, INC.
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2001-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6211105
• 关键词: biomedical equipment development; biosensor device; blood glucose; consumable /disposable biomedical equipment; diabetes mellitus; electrochemistry; miniature biomedical equipment; patient monitoring device; silicon

DESCRIPTION: (Adapted from the applicant's abstract) Recent widely-accepted advances in electrochemical biosensor technology will be combined with the unique silicon microfabrication technology developed in this laboratory to produce low cost single-use disposable (consumable) devices for painless physiological measurements. The silicon devices will consist of a microneedle comparable in cross-section to a human hair integrated with a cuvette containing a miniaturized biosensor The analyte chosen for the proposed project will be glucose, because glucose biosensors are the most advanced and diabetic glucose self-testing is the largest existing biosensor market Opportunity. The combination of a biosensor with a silicon consumable to provide a practical technique for painless blood testing is not restricted to glucose, but is an enabling technology applicable to many other analytes. The resultant sampling and assay system will require a lower sample volume than current home-glucose testing instruments, provide a faster response and be insensitive to the blood flow pattern. By rendering insertion and removal completely painless and sharply reducing the cost, disposable integrated consumables employing electrochemical biosensor technology at its present state of development become commercially practical. PROPOSED COMMERCIAL APPLICATION: The largest commercial application for silicon biosensor consumables is diabetic blood glucose self-testing, which is currently a four billion dollar per year market. Other markets include emergency medicine, control of blood levels of therapeutic drugs, and physiological monitoring of many analytes for clinical and research purposes.

描述：（改编自申请人的摘要）最近广泛接受 电化学生物传感器技术的进步将与 独特的硅微加工技术在这个实验室开发， 生产低成本的一次性使用（消耗品）设备， 生理测量。硅器件将包括一个微针 其横截面与集成有比色皿的人发相当 包含一个小型化的生物传感器。 将是葡萄糖，因为葡萄糖生物传感器是最先进的糖尿病 葡萄糖自我检测是现有生物传感器最大的市场机会。的 生物传感器与硅消耗品的组合，以提供实用的 无痛验血技术并不局限于葡萄糖， 使得技术能够适用于许多其他分析物。结果抽样 并且测定系统将需要比当前的家用葡萄糖更低的样品体积 测试仪器，提供更快的响应，对血液不敏感 流型通过使插入和取出完全无痛， 大幅降低成本，一次性集成耗材采用 电化学生物传感器技术以其目前的发展状态成为 商业实用。 拟定商业应用： 硅生物传感器耗材的最大商业应用是糖尿病血液 葡萄糖自我检测，这是目前每年40亿美元的市场。 其他市场 包括急救医学、治疗药物血液水平控制以及生理 用于临床和研究目的的许多分析物的监测。