SLOW, LATENT & TEMPERATE VIRUS INFECTIONS

缓慢、潜伏

• 批准号: 6340325
• 负责人: THOMAS J ROWELL
• 金额: --
• 依托单位: UNIVERSITY OF LOUISIANA AT LAFAYETTE
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-10-31 至 2003-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6340325
• 关键词: Ceboidea; Cercopithecidae; Macaca mulatta; Pan; Primates; animal breeding; animal care; animal colony; communicable disease control; communicable disease diagnosis; communicable disease transmission; disease /disorder model; latent virus infection; neurotropic virus; spongiform encephalopathy; virus infection mechanism

Research efforts concerning the viral study aspect of the contract are focused to determine the safety of the national blood supply in the United States and its military forces serving throughout the world; in the public health safety of animal derived food products; and the development and improvement of sensitive and specific diagnostic tests which will permit the introduction of therapeutic regimens that will either radiate the disease process or block the progression of the various infectious agents known, or suspected, to result in disease that has collectively been identified as Transmissible Spongiform Encephalopathies (TSEs). The contractor provides care, housing, and research support for nonhuman primates assigned to the Laboratory of Central Nervous System Studies, NINDS, in their effort to accomplish these goals. The contractor is responsible for monitoring nonhuman primates that have been, or will be, inoculated via various routes, with tissues known, or suspected to be, infected with one of the TSE agents, recording findings, and performing appropriate procedures to provide the Project Officer with animal samples for evaluation. The objective of the rhesus breeding aspect of the contract is to develop a colony of rhesus macaques capable of providing NINDS scientists with an uninterrupted supply of age-specific, disease-free macaques to continue on-going research projects and initiate new studies.

有关合同病毒研究方面的研究工作集中在确定美国国家血液供应及其在世界各地服役的军队的安全性；动物源性食品的公共卫生安全；开发和改进敏感和特异的诊断测试，从而允许采用治疗方案，要么辐射疾病进程，要么阻止已知或怀疑导致被共同确定为传染性海绵状脑病（tse）的各种传染因子的发展。承包商为分配给中枢神经系统研究实验室（NINDS）的非人灵长类动物提供护理、住房和研究支持，帮助它们努力实现这些目标。承包商负责监测已经或将通过各种途径接种的非人类灵长类动物，其组织已知或怀疑感染了一种TSE代理商，记录结果，并执行适当的程序，为项目官员提供用于评估的动物样本。合同中恒河猴繁殖方面的目标是开发一个恒河猴群，能够不间断地为NINDS科学家提供特定年龄、无病的恒河猴，以继续进行正在进行的研究项目并开展新的研究。