QTL ANALYSIS OF AGE RELATED PHENOTYPES

年龄相关表型的QTL分析

• 批准号: 6357691
• 负责人: GERALD E MCCLEARN
• 金额: $ 6.53万
• 依托单位: PENNSYLVANIA STATE UNIVERSITY, THE
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-02-01 至 2004-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6357691
• 关键词: aging; genetic markers; linkage mapping; phenotype; quantitative trait loci

The broad objective of this program project proposal is to maintain two different groups of genetically defined mice under highly controlled laboratory conditions and assess cross-sectional samples of these mice on a variety of age-related behavioral, immunological, physiological, neurobiological, and pathological processes at three ages, representing young adulthood, midlife and old age. Longevity will be determined in a separate group. These animals-recombinant inbred (RI) strains derived from the C57BL/6 and DBA/2 inbred strains and an F2 generation derived from these same progenitor strains-- are complementary elements in a two-phase program of identify chromosomal locations of genes ("quantitative trait loci" or QTLs) that influence complex age-related traits. The localization of such QTLs will open up valuable research approaches both to the reductionist explorations of the mechanisms of aging processes, and also the integrative science relating interactions among genes and between genes and environmental factors in influencing the phenomena of aging.

该项目的总体目标是保持两个 在高度控制的条件下， 实验室条件和评估这些小鼠的横截面样品 对各种年龄相关的行为，免疫，生理， 神经生物学和病理过程在三个年龄，代表 青年、中年和老年。寿命将在一个 单独的组。这些动物-重组近交系（RI）衍生 从C57 BL/6和DBA/2近交系和衍生的F2代， 来自这些相同的祖先菌株--是一个 基因染色体定位的两阶段程序 数量性状基因座（quantitative trait loci，简称QTLs），影响复杂的年龄相关基因。 性状这些QTL的定位将开辟有价值的研究 方法都还原论的机制的探索， 衰老过程，以及与相互作用有关的综合科学， 基因间以及基因与环境因素间的相互影响 老化的现象。