Applying Exercise Intervention to Drug Treatment

将运动干预应用于药物治疗

• 批准号: 6420700
• 负责人: RICHARD A BROWN
• 金额: $ 26.99万
• 依托单位: BUTLER HOSPITAL (PROVIDENCE, RI)
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-30 至 2004-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6420700
• 关键词: adult human (21+); aerobic exercise; behavior therapy; behavioral /social science research tag; breath tests; cardiovascular function; clinical trials; depression; drug controls; goal oriented behavior; health behavior; human subject; human therapy evaluation; interview; longitudinal human study; method development; motivation; outcomes research; patient oriented research; psychological reinforcement; questionnaires; statistics /biometry; substance abuse related behavior; substance abuse related disorder; therapy compliance; urinalysis

DESCRIPTION: (provided by applicant) Intervention to increase exercise in drug dependent patients represents a potentially useful yet unexplored strategy for preventing relapse. There are currently no established exercise interventions for use with this population. The long-term objectives of this research program are to improve treatment options for drug dependent patients by developing and establishing the efficacy of a supervised aerobic exercise intervention and to advance knowledge of the relationship between physical activity and substance use outcomes. In the present application, we propose to develop a supervised aerobic exercise (SAE) intervention for drug dependent patients and to conduct a preliminary, randomized clinical trial, examining its efficacy in comparison to a brief advice (BA) exercise intervention. In the first phase of this project (Year 1), we will develop and pilot the SAE intervention with 20 patients completing an intensive day and evening alcohol and drug treatment program. We will also develop a behavioral component to promote exercise adherence, including clinician and patient manuals. In the second phase (Years 2 & 3) we will conduct a preliminary, randomized trial with 50 sedentary drug dependent patients to examine the efficacy of the SAE intervention relative to the BA comparison condition over a six-month follow-up period. We expect that, relative to the BA condition, participants randomized to the SAE condition will demonstrate better substance use outcomes as well as improved mood, depressive symptoms, and cardiorespiratory fitness. If the efficacy of this intervention can be established in this trial and in subsequent clinical trials, drug dependent patients will be provided with a valuable adjunct or alternative to traditional substance abuse treatment.

描述：（申请人提供） 增加药物依赖患者运动的干预措施代表了一种 预防复发的潜在有用但尚未探索的策略。有 目前还没有确定的运动干预措施用于这一人群。 这项研究计划的长期目标是改善治疗 通过开发和确定疗效为药物依赖患者提供选择 一个有监督的有氧运动干预，并推进知识的 身体活动和物质使用结果之间的关系。 在本申请中，我们提出开发有监督的有氧运动， (SAE)为药物依赖患者提供干预， 随机临床试验，检查其疗效相比，一个简短的 建议（BA）进行干预。在该项目的第一阶段（第一年）， 我们将开发和试点SAE干预，20名患者完成了一项 白天和晚上的酒精和药物强化治疗计划。我们还将 发展一个行为组成部分，以促进锻炼的坚持性，包括 临床医生和患者手册。在第二阶段（第二年和第三年），我们将 对50名久坐不动的药物依赖者进行初步随机试验， 检查SAE干预相对于BA的疗效 在六个月的随访期内进行比较。 我们预计，相对于BA条件，随机分配到 SAE状况将证明更好的物质使用结局以及 改善情绪、抑郁症状和心肺功能。如果 在本试验中可以确定这种干预的有效性， 在随后的临床试验中，药物依赖患者将获得 传统药物滥用治疗的有价值的辅助或替代方法。