MI for Teen Substance Abuse with Psychiatric Comorbidity

青少年药物滥用与精神共存疾病的 MI

• 批准号: 6952236
• 负责人: RICHARD A BROWN
• 金额: $ 52.24万
• 依托单位: BUTLER HOSPITAL (PROVIDENCE, RI)
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-20 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6952236
• 关键词: adolescence (12-20); behavior modification; behavioral /social science research tag; breath tests; clinical research; comorbidity; drug /alcohol abstinence; drug detection; goal oriented behavior; human subject; human therapy evaluation; interview; longitudinal human study; mental disorders; motivation; outcomes research; posthospitalization care; psychotherapy; questionnaires; saliva; social psychology; substance abuse related disorder

DESCRIPTION (provided by applicant): Adolescents with substance use disorders frequently suffer from concomitant psychiatric disorders. Unfortunately, substance use problems among adolescents presenting for psychiatric treatment are often not adequately assessed or addressed despite the deleterious consequences of this comorbid psychopathology. The overall objective of this research program is to develop effective brief intervention approaches to address substance use problems in high-risk adolescents with comorbid psychiatric disorders, and to advance our knowledge of the relationship between psychiatric and substance use disorders within the context of a treatment outcome study. The proposed study will test the comparative efficacy of a tailored, social learning-based brief motivational intervention with personalized feedback compared to treatment as usual for reducing substance use in adolescents hospitalized with comorbid substance use and psychiatric disorders. We will also test the effects of treatment on intermediate variables such as substance use problems, psychiatric symptoms, motivation to change and post-hospitalization treatment involvement, and will examine the mechanisms of change. The study is a randomized (by cohort), two group design with repeated measures over time, comparing the efficacy of: (a) a tailored, brief motivational interviewing intervention with personalized feedback (MI) vs. (b) treatment as usual (TAU). A sample of 250 adolescent psychiatric inpatients between the ages of 13 and 17 will be recruited into the study. Subjects will meet criteria for one of more DSM-IV (non-nicotine) substance use disorders and for one or more additional current Axis I disorders, other than a substance use disorder. Subjects will be followed for 12 months, and self-reported abstinence from substance use will be verified using breath analysis and saliva drug tests. We expect that this study will result in the development of a specialized, efficacious intervention approach for the significant percentage of adolescents with comorbid substance use and psychiatric disorders, and will therefore have important clinical and public health implications.

描述（由申请人提供）： 患有药物使用障碍的青少年经常患有精神疾病。不幸的是，尽管这种合并症的精神病理学造成了有害的后果，但在为精神病治疗的青少年中的药物使用问题通常没有得到充分评估或解决。该研究计划的总体目的是开发有效的简短干预方法，以解决患有合并症的高危青少年的物质使用问题，并在治疗结果研究的背景下促进我们对精神病和药物使用障碍之间关系的了解。 拟议的研究将测试与治疗相比，基于社会学习的量身定制的，基于社会学习的简短动机干预措施与往常的治疗相比，用于减少与合并症药物使用和精神疾病住院的青少年的药物使用。我们还将测试治疗对中间变量的影响，例如药物使用问题，精神病症状，改变和院后治疗的动机，并将检查变化的机制。 这项研究是一项随机（通过队列），两组设计随着时间的推移而重复措施，比较了：（a）一种量身定制的，简短的动机访谈干预措施与个性化反馈（MI）vs.（b）照常治疗（tau）。该研究将招募250名青少年精神病患者在13至17岁之间的样本。受试者将符合更多DSM-IV（非纽约定）物质使用障碍之一的标准，除一种或多种当前轴I疾病（除了药物使用障碍之外）。将遵循受试者12个月，并将使用呼吸分析和唾液药物测试来验证对使用物质使用的自我戒酒。 我们预计这项研究将导致一种专门的，有效的干预方法，用于相同比例的合并药物使用和精神疾病的青少年，因此将具有重要的临床和公共卫生影响。