CHARACTERIZATION & IDENTIFICATION OF 20S PROTEASOME SUBUNITS

特征描述

• 批准号: 6308854
• 负责人: Ching Chung WANG
• 金额: $ 0.99万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-03-01 至 2002-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6308854
• 关键词: animal tissue; bacteria; biomedical resource; proteins; spectrometry; structural biology; technology /technique

20S proteasomes are intracellular multifunctional proteinase with molecular weight of ~750 KDa, which are composed of multiple subunits with molecular masses of 21 to 34 KDa. In order to understand the function of 20S proteasome subunits individually, it is necessary to study the structural information of each subunit. Mass spectrometry is a powerful technique for this purpose.

20S蛋白酶体是细胞内多功能蛋白酶， 分子量约为750 kDa，由多个亚基组成 分子质量为21至34 kDa。 为了了解 20S蛋白酶体亚基的功能单独，有必要 研究每个亚基的结构信息。 质谱法 为此目的是一种强大的技术。