PROSPECTIVE STUDY OF DIET AND CANCER IN MEN (HEALTH PROFESSIONALS FOLLOWUP)

我们建议继续对51 529名男性保健专业人员进行跟踪， 1986年，40至75岁，以解决一系列饮食假设 与大肠癌、前列腺癌、肺癌和黑色素瘤有关。我们 已经记录了各种各样的摄入量的实质性变化， 以及我们的饮食能力 调查问卷，在1986年，1990年和1994年管理，以捕捉这一点， 变化量对两年期后续行动调查表的答复至少 百分之九十四1987年，我们收集了腰围和臀围的数据， 1996年更新。 在1994年，我们收集并储存在液氮中， 18,000名参与者的血浆和DNA样本进行的分析 在本资助期间， 关于结肠癌和前列腺癌的长期假设，以及 还提出了几个新的和有希望的方向。 我们提出的具体目标建立在，扩展和完善我们的观察， 已经做了，部分使用生物标本，以解决一个 一系列潜在的基因-饮食相互作用。在拟议的后续行动期间 我们预计总共有607例大肠癌和2164例 前列腺癌 有了这些数据， 诱导期（这可能对结肠炎特别重要） 癌症），计算相对精确的影响估计，并检查 潜在的营养相互作用。饮食记录的可用性 队列子样本中的数据和我们小组开发的统计方法 允许计算相对风险估计值和置信区间 校正测量误差。饮食的重复测量，而不是 在任何其他大型男性队列中，将允许评估 长期饮食摄入量和饮食变化与 男性的重要癌症

We propose to continue the follow-up of 51,529 male health professionals, aged 40 to 75 years in 1986, to address a series of dietary hypotheses related to cancers of the large bowel, prostate, lung, and melanoma. We have documented substantial variation in intake of a wide variety of nutrients in this population as well as the ability of our dietary questionnaire, administered in 1986, 1990, and 1994, to capture this variation. Response to biennial follow-up questionnaires has been at least 94%. In 1987 we collected data on waist and hip circumferences, which will be updated in 1996. In 1994 we collected, and stored in liquid nitrogen, plasma and DNA specimens from 18,000 participants. Analyses conducted during the current funding period have contributed importantly to several long-standing hypotheses regarding cancers of the colon and prostate, and have also suggested several new and promising directions. Our proposed specific aims build upon, extend, and refine observations we have already made, in part using the biological specimens to address a series of potential gene-diet interactions. During the proposed follow-up we anticipate a total of 607 cases of large bowel cancer and 2164 cases of prostate cancer. With this data we will be able to examine longer induction periods (which are likely to be particularly important for colon cancer), compute relatively precise estimates of effects, and examine potential nutrient-nutrient interactions. The availability of diet record data in a cohort subsample and statistical methods developed by our group allow the computation of relative risk estimates and confidence intervals corrected for measurement error. The repeated measurements of diet, not available in any other large cohort of men, will allow an assessment of the relation of longterm dietary intakes and change in diet to risks of important cancers in men.