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STRUCTURE/FUNCTION DYNAMICS OF NGF RECEPTORS

STRUCTURE/FUNCTION DYNAMICS OF NGF RECEPTORS
NGF 受体的结构/功能动力学
批准号：
6610949
负责人：
David E. Wolf
金额：
$16.11万
依托单位：
SENSOR TECHNOLOGIES, INC.
依托单位国家：
美国
项目类别：
财政年份：
1993
资助国家：
美国
项目状态：
已结题
起止时间：
1993-08-01 至 2003-03-31
来源：
https://reporter.nih.gov/project-details/6610949
关键词：
PC12 cells biological signal transduction biophysics confocal scanning microscopy conformation dimer fluorescence microscopy fluorescence spectrometry glycoproteins growth factor receptors image processing immunofluorescence technique membrane activity neurotrophic factors photochemistry protein engineering protein structure function protein tyrosine kinase radiofluorescent probe receptor binding receptor expression recombinant proteins stoichiometry

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英文摘要
DESCRIPTION (Adapted from applicant's abstract): Nerve growth factor (NGF) is a protein required for the development, maintenance, and repair of the nervous system. There are two NGF receptors, gp75 and the tyrosine kinase TrkA. Both of these receptors can signal separately and they synergize with each other to activate multiple signal transduction pathways. The investigators hypothesize that NGF-induced receptor dimerization and clustering are the initiating These studies may provide a physical basis for NGF receptor signaling and, thereby, aid the development of new approaches for enhancing neuronal survival following trauma or during neurodegenerative disease.
期刊论文(8)
专著(0)
科研奖励(0)
会议论文
Fundamentals of fluorescence and fluorescence microscopy.
荧光和荧光显微镜基础知识。
DOI： 10.1016/s0091-679x(03)72009-3
发表时间： 2003
期刊： Methods in cell biology
影响因子： --
作者： [Wolf,DavidE]
通讯作者： Wolf,DavidE
The optics of microscope image formation.
显微镜图像形成的光学。
DOI： --
发表时间： 2003
期刊： Methods in cell biology.
影响因子： --
作者： [Wolf,DavidE]
通讯作者： Wolf,DavidE
Fluorescence correlation spectroscopy: molecular complexing in solution and in living cells.
DOI： 10.1016/s0091-679x(03)72022-6
发表时间： 2003-01-01
期刊： Methods in cell biology
影响因子： --
作者： [Bulseco, Dylan A, Wolf, David E]
通讯作者： Wolf, David E
Feedback control of the metaphase-anaphase transition in sea urchin zygotes: role of maloriented chromosomes.
DOI： 10.1083/jcb.126.1.189
发表时间： 1994-07
期刊： JOURNAL OF CELL BIOLOGY
影响因子： 7.8
作者： [Sluder, G, Miller, F J, Thompson, E A, Wolf, D E]
通讯作者： Wolf, D E
Instrument for Single Molecule Sequencing of Alzheimer's-Relevant Genomic Oxidati
Optical Surgical Probe for Assessing Human Oral Mucosa Graft Vascularization
Device for Measuring Capillary Blood Flow and the Onset of Shock
Improved Pathogen Detection by Fluorescence Correlation
  • 批准号：
    6791620
  • 项目类别：
  • 资助金额：
    $47.89万
  • 财政年份：
    2004
  • 负责人：
    David E. Wolf
  • 依托单位：
    SENSOR TECHNOLOGIES, INC.
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