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STRUCTURE/FUNCTION DYNAMICS OF NGF RECEPTORS

STRUCTURE/FUNCTION DYNAMICS OF NGF RECEPTORS
NGF 受体的结构/功能动力学
批准号：
6187250
负责人：
David E. Wolf
金额：
$33.76万
依托单位：
UNIV OF MASSACHUSETTS MED SCH WORCESTER
依托单位国家：
美国
项目类别：
财政年份：
1993
资助国家：
美国
项目状态：
已结题
起止时间：
1993-08-01 至 2002-03-31
来源：
https://reporter.nih.gov/project-details/6187250
关键词：
PC12 cells biological signal transduction biophysics confocal scanning microscopy conformation dimer fluorescence microscopy fluorescence spectrometry glycoproteins growth factor receptors image processing immunofluorescence technique membrane activity neurotrophic factors photochemistry protein engineering protein structure function protein tyrosine kinase radiofluorescent probe receptor binding receptor expression recombinant proteins stoichiometry

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DESCRIPTION (Adapted from applicant's abstract): Nerve growth factor (NGF) is a protein required for the development, maintenance, and repair of the nervous system. There are two NGF receptors, gp75 and the tyrosine kinase TrkA. Both of these receptors can signal separately and they synergize with each other to activate multiple signal transduction pathways. The investigators hypothesize that NGF-induced receptor dimerization and clustering are the initiating These studies may provide a physical basis for NGF receptor signaling and, thereby, aid the development of new approaches for enhancing neuronal survival following trauma or during neurodegenerative disease.
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  • 批准号：
    6791620
  • 项目类别：
  • 资助金额：
    $47.89万
  • 财政年份：
    2004
  • 负责人：
    David E. Wolf
  • 依托单位：
    SENSOR TECHNOLOGIES, INC.
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