COLUMBIA CENTER FOR CHILDRENS ENVIRONMENTAL HEALTH

哥伦比亚儿童环境健康中心

• 批准号: 6087589
• 负责人: FREDERICA P PERERA
• 金额: $ 81.62万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-11-01 至 2003-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6087589
• 关键词: environmental toxicology

The aim of this study is to lower the risk of asthma in young African American and Hispanic children living in northern Manhattan through two interventions, one at the community level and one at the household level. For the Community Education Intervention (CEI) the Center and its community partners, coordinated by West Harlem Environmental Action, Inc (WE ACT) will join with other community based organizations, including Alianza Dominicana, to develop, implement, and evaluate a community wide intervention to increase awareness of environmental health hazards, particularly airborne pollutants and allergens, and educate community members to take action and events held throughout Northern Manhattan. The CEI will be delivered through a combination of written and audiovisual materials, and public meetings and events held throughout Northern Manhattan. The CEI will be evaluated with data from maternal questionnaires from the cohort of 400 mothers enrolled in the developmental studies (see Ford and Perera projects). Using a single group pre-test-post-test research design, we hypothesize that from baseline to follow-up 24 months later the CEI intervention will: 1.1 Reach 10% of the wp,em aged 18-35 living in Northern Manhattan; and 1.2 Increase the percentage pf wp,em aged 18-35 who take steps to prevent or reduce environmental hazards in their households or in the community. The household intervention will consist of an Indoor Pollution and Allergen Control childhood. When the cohort of 400 children research their second birthday, we will enroll the 120 children (30%) with the highest total IgE levels--the best predictor of asthma at any age--for a one year trial of environmental strategies to prevent asthma. Enrolled families will be randomly assigned to treatment or control studies, and we will intervene in treatment group households to (a) clean and seal the preparation that includes antioxidant vitamins A, C, and E and selenium (Se), and (c) provide the child's mother with written materials and one-to-one counseling by the health educator about the importance of and methods for reducing environmental tobacco smoke (ETS) in the home. Control group families will be given a placebo intervention that includes a multi- vitamin preparation for children that does not contain the anti-oxidant vitamins and written materials about reducing exposure to ETS. Baseline data will be collected at each child's second birthday (24 months) and follow up data will be collected at 30 months (household allergen levels) and 36 months (all measures). We hypothesize that from baseline to follow up the treatment group will have, relative to controls: 2.1 reduced plasma levels of cotinine in children; 2.2 reduced household levels of cockroach and dust mite allergen; 2.3 higher plasma levels of vitamins A, C, and E and Se in children; 2.4 lower sera levels of total, cockroach-specific, rodent-specific, and dust mite-specific IgE in children; 2.5 fewer clinical signs or symptoms of asthma or allergies in children.

这项研究的目的是降低非洲年轻人患哮喘的风险。 生活在北方曼哈顿的美国和西班牙裔儿童通过两个 一个在社区一级，一个在家庭一级。 对于社区教育干预（CEI），该中心及其 社区合作伙伴，由西哈莱姆环境行动公司协调 (WE ACT）将与其他社区组织合作，包括 多米尼加联盟，制定、实施和评估一个社区范围的 采取干预措施，提高对环境健康危害的认识， 特别是空气污染物和过敏原，并教育社区 成员采取行动和活动举行整个北方曼哈顿。的 CEI将通过书面和视听相结合的方式提供 在北方各地举行的公开会议和活动 曼哈顿。CEI将使用来自母亲的数据进行评价。 来自400名母亲的问卷调查， 发展研究（见福特和佩雷拉项目）。使用单个组 前测后测研究设计，我们假设，从基线到 随访24个月后，CEI干预将：1.1达到10%的 居住在北方曼哈顿的18-35岁妇女和儿童;以及 18-35岁妇女、儿童中采取措施预防或减少 在家庭或社区中的环境危害。的 家庭干预将包括室内污染和过敏原 控制童年当400名儿童的队列研究他们的第二个 出生时，我们将招募总IgE最高的120名儿童（30%） 水平--任何年龄哮喘的最佳预测因子--进行了一项为期一年的试验， 预防哮喘的环境策略。登记的家庭将 随机分配到治疗或对照研究，我们将进行干预， 在治疗组家庭中，（a）清洁并密封制剂， 包括抗氧化剂维生素A、C和E以及硒（Se），以及（c） 为孩子的母亲提供书面材料， 由健康教育工作者提供咨询， 减少家庭环境中的烟草烟雾（ETS）。对照组 家庭将被给予安慰剂干预，其中包括一个多- 不含抗氧化剂的儿童维生素制剂 维生素和书面材料，减少暴露于ETS。基线 数据将在每个孩子的第二个生日（24个月）收集， 将在30个月时收集随访数据（家庭过敏原水平） 和36个月（所有措施）。我们假设从基线到后续 相对于对照组，治疗组将具有：2.1减少的血浆 儿童中的可替宁水平; 2.2减少家庭蟑螂水平 和尘螨过敏原; 2.3较高的血浆维生素A、C和E水平 和硒在儿童中; 2.4降低血清总水平，蟑螂特异性， 儿童中啮齿动物特异性和尘螨特异性IgE;减少2.5 儿童哮喘或过敏的临床体征或症状。