EXTRAMURAL RESEARCH FACILITIES CONSTRUCTION

校外研究设施建设

• 批准号: 6563009
• 负责人: DAVID S FORBES
• 金额: $ 300万
• 依托单位: UNIVERSITY OF MONTANA
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-15 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6563009
• 关键词: EXTRAMURAL; RESEARCH; FACILITIES; CONSTRUCTION

DESCRIPTION (provided by applicant): The long-term objectives of this application are to provide the space and infrastructure necessary to support a major increase in critical mass of scientists capable of generating National Institutes of Health (NIH) R01 support at the UM, to support the evolution of two new interdisciplinary research Centers, and to support the introduction of two new doctoral programs in the UM's School of Pharmacy and Allied Health Sciences. With a doubling in the number of research faculty over the past two years, the existing12,000 sq. ft. of assignable research space is insufficient to support this growth and the addition of seven-to-ten new investigators over the next two years. The School is now rated17th of 82 schools of pharmacy nationwide in total NIH funding and seventh nationally in NIH funding per Ph.D. faculty member. Schools with comparable funding (Universities of Colorado, Utah, and Wisconsin) average 42,500 sq. ft. of net assignable research space. Specific Aim 1 is to provide the research laboratories, core facilities, and research support space necessary to support full development of the Centers of Biomedical Research Excellence (COBRE) Center for Structural and Functional Neuroscience (CSFN) and the Center for Environmental Health Sciences (CEHS). Specific Aim 2 is to encourage interdisciplinary research by providing space to NIH-sponsored researchers from three departments and divisions associated with the aforementioned Centers, as well as the two UM Experimental Program to Stimulate Competitive Research (EPSCoR) focus areas: Biomolecular Structure and Function and Integrated Analysis of Complex Biological Systems. Specific Aim 3 is to provide sufficient student research space and research support space to introduce two new doctoral training programs; one in toxicology (environmental health) and one in neuroscience.

描述（由申请人提供）： 该应用程序的长期目标是提供必要的空间和基础设施，以支持能够在UM产生美国国立卫生研究院（NIH）R01支持的科学家的临界质量的大幅增加，以支持两个新的跨学科研究中心的发展，并支持在药学和联合健康科学的UM学校引入两个新的博士课程。 在过去的两年里，研究人员的数量翻了一番，现有的12,000平方米。英尺可分配的研究空间不足以支持这一增长，并在未来两年内增加七到十名新的研究人员。 该学院目前在全国82所药学院中排名第17位，NIH资助总额排名第七，NIH资助的博士学位排名第七。教员。 资金相当的学校（科罗拉多大学、犹他州大学和威斯康星州大学）平均占地42,500平方米。英尺可分配的研究空间。 具体目标1是提供必要的研究实验室，核心设施和研究支持空间，以支持生物医学研究卓越中心（COBRE），结构和功能神经科学中心（CSFN）和环境健康科学中心（CEHS）的全面发展。 具体目标2是通过为NIH赞助的研究人员提供空间来鼓励跨学科研究，这些研究人员来自与上述中心相关的三个部门和部门，以及两个UM实验计划以刺激竞争性研究（EPSCoR）重点领域：生物分子结构和功能以及复杂生物系统的综合分析。 具体目标3是提供足够的学生研究空间和研究支持空间，引入两个新的博士培训课程;一个毒理学（环境卫生）和一个神经科学。

项目成果

Beta amyloid oligomers and fibrils stimulate differential activation of primary microglia.

• DOI: 10.1186/1742-2094-6-1
• 发表时间: 2009-01-05
• 期刊: JOURNAL OF NEUROINFLAMMATION
• 影响因子: 9.3
• 作者: Sondag, Cindy M.;Dhawan, Gunjan;Combs, Colin K.
• 通讯作者: Combs, Colin K.

Amyloid precursor protein mediates monocyte adhesion in AD tissue and apoE(-)/(-) mice.

• DOI: 10.1016/j.neurobiolaging.2008.10.013
• 发表时间: 2010-11
• 期刊: NEUROBIOLOGY OF AGING
• 影响因子: 4.2
• 作者: Austin, Susan A.;Combs, Colin K.
• 通讯作者: Combs, Colin K.

Expression of mutant alpha-synuclein modulates microglial phenotype in vitro.

• DOI: 10.1186/1742-2094-8-44
• 发表时间: 2011-05-09
• 期刊: Journal of neuroinflammation
• 影响因子: 9.3
• 作者: Rojanathammanee L;Murphy EJ;Combs CK
• 通讯作者: Combs CK

Amyloid precursor protein mediates a tyrosine kinase-dependent activation response in endothelial cells.

• DOI: 10.1523/jneurosci.3107-09.2009
• 发表时间: 2009-11-18
• 期刊: The Journal of neuroscience : the official journal of the Society for Neuroscience
• 作者: Austin SA;Sens MA;Combs CK
• 通讯作者: Combs CK

Adhesion of monocytes to type I collagen stimulates an APP-dependent proinflammatory signaling response and release of Abeta1-40.

• DOI: 10.1186/1742-2094-7-22
• 发表时间: 2010-03-19
• 期刊: Journal of neuroinflammation
• 影响因子: 9.3
• 作者: Sondag CM;Combs CK
• 通讯作者: Combs CK