ROLE OF CELLWALL COMPONENTS IN ENTEROCOCCAL ENDOCARDITIS
细胞壁成分在肠球菌性心内膜炎中的作用
基本信息
- 批准号:6261336
- 负责人:
- 金额:$ 5.31万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2000
- 资助国家:美国
- 起止时间:2000-12-25 至 2003-03-31
- 项目状态:已结题
- 来源:
- 关键词:Enterococcus bacterial cytopathogenic effect bacterial endocarditis bacterial proteins bacterial toxins cell wall cytokine disease /disorder model gas chromatography gene mutation genetic strain laboratory rabbit leukocyte activation /transformation microorganism conjugation pathologic process protein binding protein purification protein structure function superantigens teichoate virulence western blottings
项目摘要
DESCRIPTION (from Abstract): Enterococci are important causative agents of
a particularly serious form of bacterial endocarditis, as well as other
infections. They are now among the top three nosocomial pathogens in the
US. Infections caused by the enterococci are notoriously recalcitrant to
antibiotic treatment, and relatively little is known about the genetic and
molecular basis for the virulence of this group of bacteria. This
application seeks continued support for investigation of the role of two
cell wall components in enterococcal endocarditis. One component is a
plasmid- encoded protein called Aggregation Substance (AS), and the second
is a chromosomally-encoded factor called Enterococcal Binding Substance
(EBS), which probably contains Lipoteichoic acid as its main component. AS-
EBS binding is required to form a mating pair between bacterial cells
undergoing conjugative plasmid transfer. Our data suggest that both AS and
EBS contribute to Enterococcal Virulence in an experimental animal model of
endocarditis. One or both of these compounds may also be a toxin
responsible for lethality in severe cases of endocarditis. The four
Specific Aims of the project listed below are designed to better define the
roles of AS and EBS as virulence factors, and to identify important
structure/function relationships in these molecules. SPECIFIC AIMS:
1)Determine the molecular identity of the bacterial factor responsible for
lethality in severe experimental endocarditis infections. 2) Determine the
mechanism by which the Toxin identified in Aim 1 causes lethality. 3)
Determine the key structural features of AS and EBS required for the
enhancement of virulence by these molecules. 4) Determine the mechanism by
which expression of AS is induced in vivo.
描述(来自摘要):肠球菌是重要的致病菌
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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GARY M DUNNY其他文献
GARY M DUNNY的其他文献
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{{ truncateString('GARY M DUNNY', 18)}}的其他基金
Functional genomics analysis of colonization and persistence of Enterococcus faecalis in the gastrointestinal tract.
粪肠球菌在胃肠道中定植和持续存在的功能基因组学分析。
- 批准号:
9215645 - 财政年份:2016
- 资助金额:
$ 5.31万 - 项目类别:
Pathway for functional characterization of hypothetical genes and non-coding RNAs of Enterococcus faecalis
粪肠球菌假设基因和非编码 RNA 功能表征途径
- 批准号:
8986937 - 财政年份:2015
- 资助金额:
$ 5.31万 - 项目类别:
Lactic Acid Bacteria that Detect & Inhibit Enterococci in the Mammalian GI Tract
检测的乳酸菌
- 批准号:
9060971 - 财政年份:2014
- 资助金额:
$ 5.31万 - 项目类别:
Lactic Acid Bacteria that Detect & Inhibit Enterococci in the Mammalian GI Tract
检测的乳酸菌
- 批准号:
9272922 - 财政年份:2014
- 资助金额:
$ 5.31万 - 项目类别:
Lactic Acid Bacteria that Detect & Inhibit Enterococci in the Mammalian GI Tract
检测的乳酸菌
- 批准号:
8747170 - 财政年份:2014
- 资助金额:
$ 5.31万 - 项目类别:
Invasion and Exclusion by Enterococcus faecalis in the Manduca gut community
粪肠球菌对天蛾肠道群落的入侵与排除
- 批准号:
8412944 - 财政年份:2012
- 资助金额:
$ 5.31万 - 项目类别:
4th ASM Conference on Cell-Cell Communication in Bacteria
第四届 ASM 细菌细胞间通讯会议
- 批准号:
8205337 - 财政年份:2011
- 资助金额:
$ 5.31万 - 项目类别: