ROLE OF CELLWALL COMPONENTS IN ENTEROCOCCAL ENDOCARDITIS

细胞壁成分在肠球菌性心内膜炎中的作用

基本信息

  • 批准号:
    6261336
  • 负责人:
  • 金额:
    $ 5.31万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2000
  • 资助国家:
    美国
  • 起止时间:
    2000-12-25 至 2003-03-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (from Abstract): Enterococci are important causative agents of a particularly serious form of bacterial endocarditis, as well as other infections. They are now among the top three nosocomial pathogens in the US. Infections caused by the enterococci are notoriously recalcitrant to antibiotic treatment, and relatively little is known about the genetic and molecular basis for the virulence of this group of bacteria. This application seeks continued support for investigation of the role of two cell wall components in enterococcal endocarditis. One component is a plasmid- encoded protein called Aggregation Substance (AS), and the second is a chromosomally-encoded factor called Enterococcal Binding Substance (EBS), which probably contains Lipoteichoic acid as its main component. AS- EBS binding is required to form a mating pair between bacterial cells undergoing conjugative plasmid transfer. Our data suggest that both AS and EBS contribute to Enterococcal Virulence in an experimental animal model of endocarditis. One or both of these compounds may also be a toxin responsible for lethality in severe cases of endocarditis. The four Specific Aims of the project listed below are designed to better define the roles of AS and EBS as virulence factors, and to identify important structure/function relationships in these molecules. SPECIFIC AIMS: 1)Determine the molecular identity of the bacterial factor responsible for lethality in severe experimental endocarditis infections. 2) Determine the mechanism by which the Toxin identified in Aim 1 causes lethality. 3) Determine the key structural features of AS and EBS required for the enhancement of virulence by these molecules. 4) Determine the mechanism by which expression of AS is induced in vivo.
描述(来自摘要):肠球菌是重要的致病菌

项目成果

期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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GARY M DUNNY其他文献

GARY M DUNNY的其他文献

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{{ truncateString('GARY M DUNNY', 18)}}的其他基金

Functional genomics analysis of colonization and persistence of Enterococcus faecalis in the gastrointestinal tract.
粪肠球菌在胃肠道中定植和持续存在的功能基因组学分析。
  • 批准号:
    9215645
  • 财政年份:
    2016
  • 资助金额:
    $ 5.31万
  • 项目类别:
Pathway for functional characterization of hypothetical genes and non-coding RNAs of Enterococcus faecalis
粪肠球菌假设基因和非编码 RNA 功能表征途径
  • 批准号:
    8986937
  • 财政年份:
    2015
  • 资助金额:
    $ 5.31万
  • 项目类别:
Lactic Acid Bacteria that Detect & Inhibit Enterococci in the Mammalian GI Tract
检测的乳酸菌
  • 批准号:
    9060971
  • 财政年份:
    2014
  • 资助金额:
    $ 5.31万
  • 项目类别:
Lactic Acid Bacteria that Detect & Inhibit Enterococci in the Mammalian GI Tract
检测的乳酸菌
  • 批准号:
    9272922
  • 财政年份:
    2014
  • 资助金额:
    $ 5.31万
  • 项目类别:
Lactic Acid Bacteria that Detect & Inhibit Enterococci in the Mammalian GI Tract
检测的乳酸菌
  • 批准号:
    8747170
  • 财政年份:
    2014
  • 资助金额:
    $ 5.31万
  • 项目类别:
Invasion and Exclusion by Enterococcus faecalis in the Manduca gut community
粪肠球菌对天蛾肠道群落的入侵与排除
  • 批准号:
    8412944
  • 财政年份:
    2012
  • 资助金额:
    $ 5.31万
  • 项目类别:
4th ASM Conference on Cell-Cell Communication in Bacteria
第四届 ASM 细菌细胞间通讯会议
  • 批准号:
    8205337
  • 财政年份:
    2011
  • 资助金额:
    $ 5.31万
  • 项目类别:
Biofilms and Enterococcus faecalis Biology
生物膜和粪肠球菌生物学
  • 批准号:
    8038029
  • 财政年份:
    2005
  • 资助金额:
    $ 5.31万
  • 项目类别:
Biofilms and Enterococcus faecalis Biology
生物膜和粪肠球菌生物学
  • 批准号:
    6968394
  • 财政年份:
    2005
  • 资助金额:
    $ 5.31万
  • 项目类别:
Biofilms and Enterococcus faecalis Biology
生物膜和粪肠球菌生物学
  • 批准号:
    8582526
  • 财政年份:
    2005
  • 资助金额:
    $ 5.31万
  • 项目类别:
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